PUBLICATIONS
Publications by Research Area
New Reaction Development: Metal-Catalyzed Cycloadditions
Total Synthesis of Complex Molecules
Drug Design, Synthesis and Biological Evaluation
All Publications
384. Czerwinski, D., Abu Saleh, N., Khasnavis, S., Huancas, C., Calla, N., Waymouth, R., Wender, P., Levy, R. Idiotype mRNA therapeutic vaccination in a mouse model of B cell lymphoma R. Elsevier., Blood (2025) 146 (Supplement 1): 1780.
383. Sewack, A. B., Manning, M. R., Blazkova, J., Justement, J. S., Shi, V., Praiss, L., Dasari, S., Gittens, K., Seamon, C. A., Wender, P. A., Sneller, M. C., Moir, S., Chun, T. Hide “Correlations among quantitative assays that measure the size of HIV reservoirs in people with HIV receiving antiretroviral therapy” AIDS (London, England) 2025; 39 (13): 1982-1984.
382. Mahmoud M. Abd Elwakil, Jeffery Ni, Summer Ramsay-Burrough, Paul Joshua Hurst, Rebecca L. McClellan, Samuel R. Khasnavis, Yuan Jia, Sehar R. Masud, Timothy R. Blake, Adrienne Sallets, Ole A. W. Haabeth, Idit Sagiv-Barfi, Debra K. Czerwinski, Marco Herrera-Barrera, Ronald Levy, Paul A. Wender, Maya E. Kumar, Robert M. Waymouth “In vivo mRNA delivery to the lung vascular endothelium by dicationic Charge-Altering Releasable Transporters” Journal of the American Chemical Society 2025, 147, 44, 40146-40157. DOI: 10.1021/jacs.5c06654
381. Roy van der Meel, Paul Wender, Olivia Merkel, Irene Lostalé-Seijo, Javier Montenegro, Ali Miserez, Quentin Laurent, Hanadi Sleiman, and Paola Luciani “Next-generation materials for nucleic acid delivery“ Nature Reviews Materials (viewpoint) Nature Reviews Materials 2025, 10, 490–499. https://doi.org/10.1038/s41578-025-00814-1
380. Zhijian Li, Aloysius Ee, Laura Amaya, Jennifer L. Hamad, Pavan K. Yadav, Sean K. Wang, Howard Y. Chang, Paul A. Wender “Discrete Immolative Guanidinium Transporters deliver mRNA to specific organs and red blood cells” Nature Communications 2025, 16 (1): 7055
379. Zachary O. Gentry, Owen D. McAteer, Jennifer L. Hamad, Jose A. Moran, Jocelyn T. Kim, Matthew D. Marsden, Jerome A. Zack, Paul A. Wender “Synthesis and Preclinical Evaluation of Tigilanol Tiglate Analogs as Protein Kinase C Modulators for the Eradication of HIV”, Science Advances 2025, 11, eads1911.
378. Blazkova J, Whitehead EJ, Schneck R, Shi V, Justement JS, Rai MA, Kennedy BD, Manning MR, Praiss L, Gittens K, Wender PA, Oguz C, Lack J, Moir S, Chun TW. "Immunologic and virologic parameters associated with HIV DNA reservoir size in people living with HIV receiving clinically effective antiretroviral therapy" J Infect Dis. 2024; 229(6):1770-1780. doi: 10.1093/infdis/jiad595.PMID: 38128541
377. Rahn, Harrison P.; Liu, Xinyu; Chosy, Madeline B.; Sun, Jiuzhi; Cegelski, Lynette; Wender, Paul A. Biguanide-Vancomycin Conjugates are Effective Broad-Spectrum Antibiotics against Actively Growing and Biofilm-Associated Gram-Positive and Gram-Negative ESKAPE Pathogens and Mycobacteria, Journal of the American Chemical Society 2024, 146, 32, 22541-22552; DOI: 10.1021/jacs.4c06520 https://pubs.acs.org/articlesonrequest/AOR-6XHDPXB6GCCF8M46KJFK
376. Harrison P. Rahn, Jiuzhi Sun, Zhijian Li, Robert M. Waymouth, Ronald Levy, Paul A. Wender Isoprenoid CARTs: in vitro and in vivo mRNA Delivery by Charge-Altering Releasable Transporters Functionalized with Archaea-inspired Branched Lipids, Biomacromolecules 2024, 25, 7, 4305-4316 https://doi.org/10.1021/acs.biomac.4c00373
375. Overall, Sarah; Hartmann, Sina; Luu-Nguyen, Quang; Judge, Patrick; Pinotsi, Dorothea; Marti, Lea; Sigurdsson, Snorri; Wender, Paul; Barnes, Alexander “Topological heterogeneity of protein kinase C modulators in human T-cells resolved with in-cell dynamic nuclear polarization NMR spectroscopy” Journal of the American Chemical Society, 2024, 146, 40, 27362-27372. DOI: 10.1021/jacs.4c05704
374. Zhijian Li, Laura Amaya, Aloysius Ee, Sean Wang, Alok Ranjan, Robert M. Waymouth, Howard Chang*, Paul A. Wender* “Organ and Cell Selective Delivery of RNA in vivo Using Guanidinylated Serinol Charge-altering Releasable Transporters (GSer-CARTs)” Journal of the American Chemical Society, 2024, 146, 21, 14785-14798. DOI: 10.1021/jacs.4c02704
373. Dimapasoc M, Moran JA, Cole SW, Ranjan A, Hourani R, Kim JT, Wender PA, Marsden MD,Zack JA. Defining the Effects of PKC Modulator HIV Latency-Reversing Agents on Natural Killer Cells. Pathogens and Immunity 2024; 9(1):108–137. doi: 10.20411/pai.v9i1.673
372. Shanmukha, S., Godfrey, W. H., Gharibani, P., Lee, J. J., Guo, Y., Deng, X., Wender, P. A., Kornberg, M. D., Kim, P. M. TPPB modulates PKC activity to attenuate neuroinflammation and ameliorate experimental multiple sclerosis. Frontiers in Cellular Neuroscience 2024; 18: 1373557. https://doi.org/10.3389/fncel.2024.1373557
371. Chosy, Madeline B.; Sun, Jiuzhi; Rahn, Harrison P.; Brcic, Jasna; Wender, Paul A.; Cegelski, Lynette “Vancomycin-polyguanidino Dendrimer Conjugates Inhibit Growth of Antibiotic-resistant Gram-positive and Gram-negative Bacteria and Eradicate Biofilm-associated S. aureus” ACS Infectious Dis 2024, 10, 2, 384–397 DOI: 10.1021/acsinfecdis.3c00168
370. Zhijian Li, Laura Amaya, Ruoxi Pi, Sean K. Wang, Alok Ranjan, Robert M. Waymouth, Catherine A. Blish, Howard Y. Chang, Paul A. Wender “Charge-altering releasable transporters with a distinct polymeric backbone enhance mRNA delivery in vitro and exhibit in vivo tropism” Nature Commun 2023, 14, 6983. https://doi.org/10.1038/s41467-023-42672-x
369. Winkler, Jeffrey D.; Wender, Paul A.; Kahne, Daniel “Gilbert Stork” Biographical Memoir, Proc. Natl. Acad. Sci. USA 2023 http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/stork-gilbert.pdf.
368. S. H. Werby, J. Brcic, M. B. Chosy, J. Sun, J. T. Rendell, L. F. Neville, P. A. Wender and L. Cegelski, Detection of Intact Vancomycin-Arginine as the Active Antibacterial Conjugate in E. coli by Whole Cell Solid-State NMR RSC Med. Chem., 2023, DOI: 10.1039/D3MD00173C
367. Laura Amaya, Lilit Grigoryan, Zhijian Li, Audrey Lee, Paul A. Wender, Bali Pulendran, Howard Y. Chang “Circular RNA vaccine induces potent T cell responses” Proc. Natl. Acad. Sci. USA 2023, 120 No. 20 e2302191120; https://doi.org/10.1073/pnas.2302191120
366. Jasna Brcic, Alan Tong, Paul A. Wender, Lynette Cegelski “Conjugation of Vancomycin with a Single Arginine Improves Efficacy Against Mycobacteria by More Effective Peptidoglycan Targeting” J. Med. Chem. 2023, 66, 15, 10226-10237. DOI: 10.1021/acs.jmedchem.3c00565 (featured article)
365. Jose A. Moran, Alok Ranjan, Rami Hourani, Jocelyn T. Kim, Paul A. Wender, Jerome A. Zack, and Matthew D. Marsden* “Secreted factors induced by PKC modulators do not indirectly cause HIV latency reversal” Virology 2023 581:8-14. doi: 10.1016/j.virol.2023.02.009. PMID: 36842270
364. Brooke D. Kennedy, Jana Blazkova, Jesse S. Justement, Victoria Shi, M. Ali Rai, Maegan R. Manning, Lauren Praiss, Kathleen Gittens, Paul A. Wender, Sean Patro, Xiaolin Wu, Susan Moir, and Tae-Wook Chun “Comprehensive analysis of HIV reservoirs in elite controllers” J Clin Invest. 2023;133(3):e165446. https://doi.org/10.1172/JCI165446.
363. Blake, Timothy R.; Haabeth, Ole A. W.; Sallets, Adrienne; McClellan, Rebecca L.; Del Castillo, Trevor J.; Vilches-Moure, Jose G.; Ho, Wilson C.; Wender, Paul A.; Levy, Ronald; Waymouth, Robert M. "Lysine-derived Charge-Altering Releasable Transporters (K-CARTs): Targeted Delivery of mRNA and siRNA to the Lungs" Bioconjugate Chemistry 2023, 34, 4, 673-685 https://doi.org/10.1021/acs.bioconjchem.3c00019
362. Robert Chen, Sean K. Wang, Julia A. Belk, Laura Amaya, Zhijian Li, Angel Cardenas, Brian T. Abe, Chun-Kan Chen, Paul A. Wender, Howard Y. Chang “Engineering circular RNA for enhanced protein production” Nature Biotechnology 2023, 41, 262-272. https://doi.org/10.1038/s41587-022-01393-0
361. Wender, Paul; Luu-Nguyen, Quang; Sloane, Jack; Ranjan, Alok "Trimethylene Methane Dianion Equivalent for the Asymmetric Consecutive Allylation of Aldehydes: Applications to Prins-Driven Macrocyclizations for the Synthesis of Bryostatin 1 and Analogues" J. Org. Chem. 2022 87, 15925−15937 https://pubs-acs-org.stanford.idm.oclc.org/doi/pdf/10.1021/acs.joc.2c02047
360. Testa, Stefano; Haabeth, Ole; Blake, Timothy; Del Castillo, Trevor; Rajapaksa, Ranjani; Czerwinski, Debra; Wender, Paul; Waymouth, Robert; Levy, Ronald "Fingolimod-conjugated charge-altering releasable transporters efficiently and specifically deliver mRNA to lymphocytes in vivo and in vitro" Biomacromolecules 2022 23, 7, 2976-2988 https://doi.org/10.1021/acs.biomac.2c00469
359. Paul A. Wender, Zachary O. Gentry, David J. Fanelli, Quang H. Luu-Nguyen, Owen D. McAteer, Edward Njoo “Practical synthesis of the therapeutic leads tigilanol tiglate and its analogues”, Nature Chemistry, 2022, 14, 1421-1426. DOI: 10.1038/s41557-022-01048-2
358. Jocelyn T. Kim, Tian-Hao Zhang, Camille Carmona, Bryanna Lee, Christopher Seet, Matthew Kostelny, Nisarg Shah, Hongying Chen, Kylie Farrell, Mohamed S.A. Soliman, Melanie Dimapasoc, Michelle Sinani, Kenia Yazmin Reyna Blanco, David Bojorquez, Hong Jiang, Yuan Shi, Yushen Du, Natalia L. Komarova, Dominik Wodarz, Paul A. Wender, Matthew D. Marsden, Ren Sun, Jerome A. Zack Latency reversal plus natural killer cells diminish HIV reservoir in vivo Nature Commun. 2022 13:121 | https://doi.org/10.1038/s41467-021-27647-0
357. Haabeth, Ole; Lohmeyer, Julian; Sallets, Adrienne; Blake, Timothy; Sagiv-Barfi, Idit; Czerwinski, Debra; McCarthy, Blaine; Powell, Abigail; Wender, Paul; Waymouth, Robert; Levy, Ronald "An mRNA SARS-CoV-2 vaccine employing Charge-Altering Releasable Transporters with a TLR-9 agonist induces neutralizing antibodies and T cell memory" ACS Central Science 2021, 7, 1191-1204. DOI: 10.1021/acscentsci.1c00361
356. Lewis F. Neville, Itamar Shalit, Peter A. Warn, Marc H. Scheetz, Jiuzhi Sun, Madeline B. Chosy, Paul A. Wender, Lynette Cegelski, Jacob T. Rendell “In vivo targeting of E. coli with vancomycin-arginine” Antimicrob Agents Chemother 2021, 65, e02416-20. https://doi.org/10.1128/AAC.02416-20
355. Matthew D. Marsden, Tian-hao Zhang, Yushen Du, Melanie Dimapasoc, Mohamed S. A. Soliman, Xiaomeng Wu, Jocelyn T. Kim, Akira Shimizu, Adam Schrier, Paul A. Wender*, Ren Sun*, and Jerome A. Zack* Tracking HIV rebound following latency reversal using barcoded HIV” Cell Reports Medicine 2020, 1, 100162. https://doi.org/10.1016/j.xcrm.2020.100162
354. Efrat Abramson, Clayton Hardman, Akira Shimizu, Soonmyung Hwang, Lynda D. Hester, Solomon H. Snyder, Paul A. Wender, Paul M. Kim, Michael D. Kornberg Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation Cell Chemical Biology 2021, 28, 28, 537-545. doi.org/10.1016/j.chembiol.2020.12.015 PMID: 33472023
353. Paul A. Wender, Jack L. Sloane, Quang H. Luu-Nguyen, Yasuyuki Ogawa, Akira J. Shimizu, Steven M. Ryckbosch, Jefferson H. Tyler, and Clayton Hardman. Function Oriented Synthesis: Design, Synthesis, and Evaluation of Highly Simplified Bryostatin Analogs J. Org. Chem. 2020, 85, 23, 15116-15128. DOI: 10.1021/acs.joc.0c01988
352. Aaron J. Wilk, Nancy L. Weidenbacher, Rosemary Vergara, Ole A.W. Haabeth, Ronald Levy, Robert M. Waymouth, Paul A. Wender, and Catherine A. Blish “Charge-Altering Releasable Transporters enable Phenotypic Manipulation of Natural Killer Cells for Cancer Immunotherapy” Blood Advances 2020, 4 (17): 4244-4255. https://doi.org/10.1182/bloodadvances.2020002355
351. Sarah A. Overall, Lauren E. Price, Brice J. Albert, Chukun Gao, Nicholas Alaniva, Patrick T. Judge, Erika L. Sesti, Paul A. Wender, George B. Kyei, and Alexander B. Barnes “In situ detection of endogenous HIV activation by dynamic nuclear polarization-NMR and flow cytometry” Int. J. Mol. Sci 2020, 21, 4649 doi:10.3390/ijms21134649
350. Ly, Calvin; Shimizu, Akira J.; Vargas, Maxemiliano V.; Duim, Whitney C.; Wender, Paul A.; Olson, David E. “Bryostatin 1 Promotes Synaptogenesis and Reduces Dendritic Spine Density in Cortical Cultures through a PKC-Dependent Mechanism” ACS Chemical Neuroscience, 2020, 11, 1545-1554 DOI: 10.1021/acschemneuro.0c00175
349. Jack L. Sloane, Nancy L. Benner, Katherine N. Keenan, Xiaoyu Zang, Mohamed S. A. Soliman, Xiaomeng Wu, Melanie Dimapasoc, Tae-Wook Chun, Matthew D. Marsden, Jerome A. Zack, Paul A. Wender “Prodrugs of PKC Modulators Show Enhanced HIV Latency Reversal and an Expanded Therapeutic Window” Proc. Natl. Acad. Sci. USA 2020, 117, (20), 10688-10698: https://doi.org/10.1073/pnas.1919408117
348. Clayton Hardman, Stephen Ho, Akira Shimizu, Quang Luu-Nguyen, Jack L. Sloane, Mohamed S. A. Soliman, Matthew D. Marsden, Jerome A. Zack, Paul A. Wender “Design, Synthesis and Evaluation of PKC Modulators for Enhanced Cancer Immunotherapy” Nature Commun 2020, 11, 1879. https://doi.org/10.1038/s41467-020-15742-7
347. Blake, Timothy; Ho, Wilson; Christopher R. Turlington, Xiaoyu Zang, Melanie Huttner, Wender, Paul, Waymouth, Robert “Synthesis and Mechanistic Investigations of pH-Responsive Cationic Poly(aminoester)s” Chemical Science 2020 11, 2951-2966 DOI: 10.1039/c9sc05267d
346. Bitnun, Ari; Ransy, Doris G.; Brophy, Jason; Kakkar, Fatima; Hawkes, Michael; Samson, Lindy; Annabi, Bayader; Pagliuzza, Amelie; Morand, Jacob-Adams; Sauve, Laura; Chomont, Nicolas; Lavoie, Stephanie; Kim, John; Sandstrom, Paul, Wender, Paul A.; Lee, Terry; Singer, Joel; Read, Stanley E.; Soudeyns, Hugo “Clinical correlates of HIV-1 DNA and inducible HIV-1 RNA reservoirs in peripheral blood in children with perinatally acquired HIV-1 infection with sustained virologic suppression for at least 5 years” Clinical Infectious Diseases 2020, 5, 859-866. https://doi-org.stanford.idm.oclc.org/10.1093/cid/ciz251
345. Antonoplis, Alexandra; Zang, Xiaoyu; Wegner, Tristan; Wender, Paul; Cegelski, Lynette "A Vancomycin-Arginine Conjugate Inhibits Growth of Carbapenem-resistant E. coli and Targets Cell-Wall Synthesis" ACS Chemical Biology 2019, 14, 9, 2065-2070 DOI: 10.1021/acschembio.9b00565
344. Jyoti Singh, Alexander Ripp, Thomas M. Haas, Danye Qiu, Manfred Keller, Paul A. Wender, Jay S. Siegel, Kim K. Baldridge, Henning J. Jessen “Synthesis of modified nucleoside oligophosphates simplified: Fast, pure, and protecting group free.” Journal of the American Chemical Society 2019, 141, 38, 15013-15017 DOI: 10.1021/jacs.9b08273
343. Erin D. Huiting, Kathleen Gittens, J. Shawn Justement, Victoria Shi, Jana Blazkova, Erika Benko, Colin Kovacs, Paul A. Wender, Susan Moir, Michael C. Sneller, Anthony S. Fauci, and Tae-Wook Chun “Impact of treatment interruption on HIV reservoirs and immune parameters in individuals who had initiated antiretroviral therapy during the early phase of infection” Journal of Infectious Diseases 2019, 2, 270-274. https://doi.org/10.1093/infdis/jiz100
342. Jyoti Singh, Nicole Steck, Debaditya De, Alexandre Hofer, Ilya Captain, Manfred Keller, Paul A. Wender, Rashna Bhandari, and Henning J. Jessen A Phosphoramidite Analogue of Cyclotriphosphate Enables Iterative phosphorylations Angewandte Chemie Int. Ed. 2019, 58(12), 3928-3933 https://doi-org.stanford.idm.oclc.org/10.1002/anie.201814366
341. Habibian, Maryam; McKinlay, Colin; Blake, Timothy; Kietrys, Anna; Waymouth, Robert; Wender, Paul; Kool, Eric “Reversible RNA Acylation for Control of CRISPR-Cas9 Gene Editing” RSC Chemical Science 2019, 11, 1011-1016. DOI: 10.1039/C9SC03639C
340. Nancy L. Benner, Rebecca L. McClellan, Christopher R. Turlington, Ole A Haabeth Robert M. Waymouth, Paul A. Wender “Synthesis of Poly(serine esters) by Organocatalytic Ring Opening Polymerization and their use as Charge-Altering Releasable Transporters for mRNA Delivery in vitro and in vivo” Journal of the American Chemical Society 2019, 141, 21, 8416-8421 DOI: 10.1021/jacs.9b03154
339. Ole A. W. Haabeth, Timothy R. Blake, Colin J. McKinlay, Anders Tveita, Robert M. Waymouth, Paul A. Wender, Ronald Levy “Local OX40L, CD80, and CD86 mRNA delivery kindles global anti-cancer immunity” Cancer Research 2019, 79 (7), 1624-1634. doi: 10.1158/0008-5472.CAN-18-2867; PubMed 30692215
338. Alexandra Antonoplis, Xiaoyu Zang, Melanie A. Huttner, Kelvin K.L. Chong, Yu B. Lee, Julia Y. Co, Manuel R. Amieva, Kimberly A. Kline, Paul A. Wender, Lynette Cegelski “A dual function antibiotic-transporter conjugate exhibits superior activity in sterilizing MRSA biofilms and killing persister cells” J. Am. Chem. Soc. 2018, 140, 16140-16151 DOI: 10.1021/jacs.8b08711
337. Gabriella M. Fernandes-Cunha, Colin J. McKinlay, Jessica R. Vargas, Henning J. Jessen, Robert M. Waymouth, and Paul A. Wender ”Delivery of Inorganic Polyphosphate, the Forgotten Biopolymer, into Cells using an Amphipathic Oligocarbonate Transporter” ACS Central Science 2018 doi: 10.1021/acscentsci.8b00470
336. Ole A. W. Haabeth, Timothy R. Blake, Colin J. McKinlay, Robert M. Waymouth, Paul A. Wender, Ronald Levy “mRNA Vaccination with Charge-Altering Releasable Transporters elicit human T cell responses, and Cures Established Tumors in mice” Proc. Natl. Acad. Sci. USA 2018 115 (39), E9153-E9161 www.pnas.org/cgi/doi/10.1073/pnas.1810002115
335. Colin J. McKinlay, Nancy L. Benner, Ole A. Haabeth, Robert M. Waymouth, and Paul A. Wender “Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters” Proc. Natl. Acad. Sci. USA 2018, 115 (26), E5859-E5866 doi.org/10.1073/pnas.1805358115
334. Matthew David Marsden, Ph.D.; Xiaomeng Wu; Sara Mottahedan; Brian Loy; Adam J Schrier; Brian A DeChristopher; Akira J Shimizu; Clayton T Hardman; Stephen Ho; Christina M Ramirez; Paul Wender; Jerome A Zack “Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents” Virology 2018, 520, 83-93 doi.org/10.1016/j.virol.2018.05.006.
333. Benner, Nancy; Near, Katherine; Bachmann, Michael; Contag, Christopher; Waymouth, Robert; Wender, Paul "Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs)" Biomacromolecules 2018 19 (7), pp 2812–2824 DOI: 10.1021/acs.biomac.8b00401
332. Hao Yang, Daryl Staveness, Steven M. Ryckbosch, Alison D. Axtman, Brian A. Loy, Alexander B. Barnes, Vijay S. Pande, Jacob Schaefer, Paul A. Wender, Lynette Cegelski “REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment” ACS Central Science, 2018, 4 (1), pp 89–96 DOI: 10.1021/acscentsci.7b00475
331. Wender, Paul A.; Ebner, Christian; Fennell, Brandon D.; Inagaki, Fuyuhiko; Schröder, Britte “Ynol Ethers as Ketene Equivalents in Rhodium-Catalyzed Intermolecular [5 + 2] Cycloaddition Reactions” Org. Lett. 2017, 19(21), 5810-5813 DOI: 10.1021/acs.orglett.7b02765
330. Liu, Bowen; Ramsundar, Bharath; Kawthekar, Prasad; Shi, Jade; Gomes, Joseph; Luu Nguyen, Quang; Ho, Stephen; Sloane, Jack; Wender, Paul; Pande, Vijay ”Retrosynthetic reaction prediction using neural sequence-to-sequence models” ACS Central Sci. 2017, 3 (10), 1103-1113. DOI: 10.1021/acscentsci.7b00303
329. Paul A. Wender, Clayton T. Hardman, Stephen Ho, Matthew S. Jeffreys, Ryan V. Quiroz, Steven M. Ryckbosch, Akira J. Shimizu, Jack L. Sloane, Matthew C. Stevens, Jana K. Maclaren “Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV” Science 2017 358, 218-223.
328. Brice Albert, Austin Niu, Rashmi Ramani, Robert M. Williams, Garland R. Marshall, Paul A. Wender, Lee Ratner, Alexander B. Barnes, George B. Kyei “Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation.” Nature Scientific Reports 2017 7: 7456 | DOI:10.1038/s41598-017-07814-4
327. Nancy L. Benner, Xiao-Yu Zang, Daniel C. Buehler, Valerie A. Kickhoefer, Michael E. Rome, Leonard H. Rome, Paul A. Wender “Vault Nanoparticles: Chemical Modifications for Imaging and Enhanced Delivery” ACS Nano 2017, 11 (1), 872–881 DOI: 10.1021/acsnano.6b07440
326. Tapan K. Khan, Paul A. Wender, Daniel L. Alkon “Bryostatin and its synthetic analog rescue dermal fibroblasts from stress and contribute to survival and rejuvenation of human skin equivalents” J. Cellular Physiology 2017, DOI 10.1002/jcp.26043
325. Matthew D. Marsden, Brian A. Loy, Xiaomeng Wu, Christina M. Ramirez, Adam J. Schrier, Danielle Murray, Akira Shimizu, Steven M. Ryckbosch, Katherine E. Near, Tae-Wook Chun, Paul A. Wender, Jerome A. Zack “In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and “kill" in strategy for virus eradication” PLoS Pathogens 2017 13(9): e1006575. https://doi.org/10.1371/journal.ppat.1006575
324. Colin J. McKinlay, Jessica R. Vargas, Timothy R. Blake, Jonathan W. Hardy, Masamitsu Kanada, Christopher H. Contag, Paul A. Wender, and Robert M. Waymouth “Charge-altering releasable transporters (CARTs) for the delivery and release of messenger RNA in living animals” Proc. Natl. Acad. Sci. USA 2017 E448-456, doi/10.1073/pnas.1614193114
323. Rana Abdelnabi, Daryl Staveness, Katherine E. Near, Paul A. Wender, Leen Delang, Johan Neyts, Pieter Leyssen “Comparative analysis of salicylate-based bryostatin analogs with or without modification at position C26 confirms that the inhibitory effect on chikungunya virus replication also involves a non-PKC-dependent mechanism” Biochemical Pharmacology 2016, 120, 15-21
322. McKinlay, Colin; Waymouth, Robert; Wender, Paul A. “Cell-Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery” J. Am. Chem. Soc. 2016, 138 (10), 3510-3517 DOI: 10.1021/jacs.5b13452
321. Steven M. Ryckbosch, Paul A. Wender, Vijay S. Pande “Molecular Dynamics Simulations Reveal Ligand-controlled Positioning of a Peripheral Protein Complex in Membranes” Nature Comm. 2017, 8, 6.
320. Staveness, Daryl; Abdelnabi, Rana; Near, Katherine; Nakagawa, Yu; Neyts, Johan; Delang, Leen; Leyssen, Pieter; Wender, Paul "Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogs Provides Additional Evidence for a PKC-Independent Pathway" J. Nat. Products, 2016, 79 (4), 680–684 DOI: 10.1021/acs.jnatprod.5b01017
319. Staveness, Daryl; Abdelnabi, Rana; Schrier, Adam; Loy, Brian; Verma, Vishal; DeChristopher, Brian; Near, Katherine; Neyts, Johan; Delang, Leen; Leyssen, Pieter; Wender, Paul "Simplified Bryostatin Analogs Protect Cells from Chikungunya Virus-Induced Cell Death" J. Nat. Products 2016 79 (4), 675–679 DOI: 10.1021/acs.jnatprod.5b01016
318. Igor Pavlovic, Divyeshsinh T. Thakor, Jessica R. Vargas, Colin J. McKinlay, Sebastian Hauke, Philipp Anstaett, Rafael C. Camuña, Laurent Bigler, Gilles Gasser, Carsten Schultz, Paul A. Wender, Henning J. Jessen “A photocaged inositol-pyrophosphate: Synthesis, cellular delivery, photochemical release, and its effect on PH-domain translocation“ Nature Comm. 2016 10622
317. Hsiao-Tieh Hsu, Brian M. Trantow, Robert M. Waymouth and Paul A. Wender "Bioorthogonal Catalysis: A General Method to Evaluate Metal-catalyzed Reactions in Real Time in Living Systems Using a Cellular Luciferase Reporter System” Bioconjugate Chem., 2016, 27 (2), 376–382 DOI: 10.1021/acs.bioconjchem.5b00469
316. Wender, Paul A. “Art, Architecture and the Molecular Frontier” Acc. Chem. Res. 2015, 48, 2169−2170.
315. Wender, Paul A.; Jeffreys, Matthew S.; Raub, Andrew G. "Tetramethyleneethane Equivalents: Recursive Reagents for Serialized Cycloadditions”, J. Am. Chem. Soc., 2015, 137 (28), 9088-9093 DOI: 10.1021/jacs.5b04091. PMID: 25961416
314. Brian A. Loy, Adam B. Lesser, Daryl Staveness, Kelvin L. Billingsley, Lynette Cegelski, Paul A. Wender* "Toward a Biorelevant Structure of Protein Kinase C Bound Allosteric Modulators: Design, Synthesis, and Evaluation of Labeled Bryostatin Analogs for Analysis with Solid-State REDOR NMR Spectroscopy" J. Am. Chem. Soc. 2015, 137(10), 3678-3685. DOI: 10.1021/ar500434f.
313. Wender, Paul; Quiroz, Ryan; Stevens, Matthew "Function Through Synthesis-Informed Design" Acc. Chem. Res. 2015, 48(3), 752-760.
312. Boudreault, Pierre-Luc; Mattler, Jennifer K.; Wender, Paul A. “Studies on the Regio- and Stereo-selective Epoxidation of Daphnanes and Tiglianes” Tetrahedron Lett. 2015 3423-3427 http://dx.doi.org/10.1016/j.tetlet.2015.01.126
311. Thomas J. L. Mustard, Paul A. Wender, Paul Ha-Yeon Cheong “Catalytic Efficiency is a Function of How Rhodium(I) (5+2)-Catalysts Accommodate a Conserved Substrate Transition State Geometry: Induced Fit Model for Explaining Transition Metal Catalysis” ACS Catalysis 2015 1758-1763 DOI: 10.1021/cs501828e.
310. Paul A. Wender, Melanie A. Huttner, Daryl Staveness, Jessica R. Vargas, Adele F. Xu “Guanidinium-rich, Glycerol-derived Oligocarbonates: A New Class of Cell-penetrating Molecular Transporters that Complex, Deliver, and Release siRNA” Molecular Pharmaceutics 2015, 12 (3), 742-750 DOI: 10.1021/mp500581r.
309. Hong, Xin; Stevens, Matthew; Liu, Peng; Wender, Paul; Houk, K. “Reactivity and Chemoselectivity of Allenes in Rh(I)-Catalyzed Intermolecular (5+2) Cycloadditions with Vinylcyclopropanes: Allene-Mediated Rhodacycle Formation Can Poison Rh(I)-Catalyzed Cycloadditions” J. Am. Chem. Soc. 2014, 136, 17273-17283.
308. Wender, Paul; Staveness, Daryl “Improved Protein Kinase C Affinity through Final Step Diversification of Simplified Salicylate-Derived Bryostatin Analog Scaffold” Organic Letters 2014 5140-5143.
307. Wender, Paul; Nakagawa, Yu; Near, Katherine; Staveness, Daryl “Computer-Guided Design, Synthesis, and Protein Kinase C Affinity of a New Salicylate-Based Class of Bryostatin Analogs” Organic Letters 2014 5136-5139.
306. Wender, P. A.; Axtman, A. D.; Golden, J. E.; Kee, J. -M.; Sirois, L. E.; Quiroz, R. V.; Stevens, M. C. “Function through Bio-Inspired, Synthesis-Informed Design: Step-Economical Syntheses of Designed Kinase Inhibitors” Org. Chem. Frontiers 2014, 1166-1171 DOI: 10.1039/C4QO00228H.
305. Paul A. Wender*, Fuyuhiko Inagaki, Magnus Pfaffenbach, Matthew C. Stevens “Propargyltrimethylsilanes as Allene Equivalents in Transition Metal Catalyzed [5+2] Cycloadditions” Organic Letters 2014, 2923-2925.
304. Vargas, Jessica R.; Geihe Stanzl, Erika; Teng, Nelson N. H.; Wender, Paul A. “Cell-penetrating, Guanidinium-rich Molecular Transporters for Overcoming Efflux-mediated Multidrug Resistance” Molecular Pharmaceutics 2014, 2553-2565. DOI: 10.1021/mp500161z
303. Wender, P. A.; Donnelly, A. C,; Loy, B. A.; Near, K. E.; Staveness, D. “Rethinking the Role of Natural Products: Function-Oriented Synthesis, Bryostatin and Bryologs” in Natural Products in Medicinal Chemistry (Ed: S. Hanessian). Wiley-VCH. 2014 Ch 14, 475-544.
302. Wender, P. A. “Toward the Ideal Synthesis and Molecular Function through Synthesis-informed Design” Natural Products Reports 2014, 31 (4), 433-440. DOI:10.1039/C4NP00013G.
301. Daniel C. Buehler, Matthew D. Marsden, Sean Shen, Daniel B. Toso, Xiaomeng Wu, Joseph A. Loo, Z. Hong Zhou, Valerie A. Kickhoefer, Paul A. Wender, Jerome A. Zack, and Leonard H. Rome “Bioengineered vaults: Self-assembling protein shell-lipophilic core nanoparticles for drug delivery” ACS Nano 2014, 8 (8), 7723–7732 DOI: 10.1021/nn5002694.
300. Wender, Paul A.; Fournogerakis, Dennis N.; Jeffreys, Matthew S.; Quiroz, Ryan V.; Inagaki, Fuyuhiko; Pfaffenbach, Magnus “Structural Complexity Through Multicomponent Cycloaddition Cascades Enabled by Dual-Purpose, Reactivity Regenerating 1,2,3-Triene Equivalents” Nature Chemistry 2014, 448-452.
299. Wender, Paul A. “Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis” Tetrahedron 2013, 7529-7550
298. Erika Geihe Stanzl, Brian M. Trantow, Jessica R. Vargas, Paul A. Wender “15 Years of Cell-Penetrating, Guanidinium-rich Molecular Transporters: Basic Science, Research Tools and Clinical Applications” Accounts 2013, 46(12), 2944-2954.
297. Wender, Paul A; Billingsley, Kelvin L. “Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13 Diversified Bryostatin Analogues” Synthesis 2013, 45 (13), 1815-1824.
296. Yasuyuki Ogawa, Phillip P. Painter, Dean J. Tantillo, and Paul A. Wender “Mechanistic and Computational Studies of Exocyclic Stereocontrol in the Synthesis of Bryostatin-like cis-2,6-Disubstituted-4-Alkylidene Tetrahydropyrans by Prins Cyclization” J. Org. Chem. 2013, 78 (1), 104-115.
295. Elizabeth J. Beans, Dennis Fournogerakis, Carolyn Gauntlett, Lars V. Heumann, Rainer Kramer, Matthew D. Marsden, Tae-Wook Chun, Jerome A. Zack, and Paul A. Wender “Highly Potent, Synthetically Accessible Prostratin Analogs Induce Latent HIV Expression in vitro and ex vivo” Proc. Natl. Acad. Sci. USA 2013, 11698-11703.
294. Xu, Xiufang; Liu, Peng; Lesser, Adam; Sirois, Lauren; Wender, Paul; Houk, K. "Ligand Effects on Rates and Regioselectivities of Rh(I)-Catalyzed (5+2) Cycloadditions: A Computational Study of Cyclooctadiene and Dinaphthocyclooctatetraene as Ligands" J. Am. Chem. Soc., 2012, 134 (26), 11012–11025.
293. DeChristopher, Brian A.; Loy, Brian A.; Marsden, Matthew D.; Schrier, Adam J.; Zack, Jerome A.; Wender, Paul A. “Designed, Synthetically Accessible Bryostatin Analogues Potently Induce Activation of Latent HIV Reservoirs” Nature Chemistry 2012, 4, 705-710.
292. Hyman, Joel M.; Geihe, Erika I.; Trantow, Brian M.; Parvin, Bahram; Wender, Paul A. “A Molecular Method for the Delivery of Small Molecules and Proteins Across the Cell Wall of Algae Using Molecular Transporters” Proc. Natl. Acad. Sci. USA 2012, 109 (33), 13225-13230.
291. Erika I. Geihe, Christina B. Cooley, Jeff R. Simon, Matthew K. Kiesewetter, Justin A. Edward, Robyn P. Hickerson, Roger L. Kaspar, James L. Hedrick, Robert M. Waymouth, Paul A. Wender “Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells” Proc. Natl. Acad. Sci. USA 2012, 109 (33), 13171-13176.
290. Lopez-Campistrous, Ana; Song, Xiaohua; Schrier, Adam J.; Wender, Paul A.; Dower, Nancy A.; Stone, James C. “Bryostatin Analogue-Induced Apoptosis in Mantle Cell Lymphoma Cell Lines” Experimental Hematology 2012, 40 (8), 646-656.e2.
289. Paul A Wender, PhD; Wesley C Galliher, PhD; Neelima M Bhat, PhD; Thomas H Pillow, PhD; Marcia M Bieber, MD; Nelson N.H. Teng, M.D., Ph.D. “Taxol-Oligoarginine Conjugates Overcome Drug Resistance in-vitro in Human Ovarian Carcinoma” Gynecologic Oncology 2012, 126, 118-123.
288. Jana Blazkova, Tae-Wook Chun, Bietel W. Belay, Danielle Murray, J. Shawn Justement, Emily K. Funk, Amy Nelson, Claire W. Hallahan, Susan Moir, Paul A. Wender and Anthony S. Fauci “Effect of Histone Deacetylase Inhibitors on HIV Production in Latently Infected, resting CD4+ T Cells from Infected Individuals Receiving Effective Antiretroviral Therapy” J. Infectious Diseases 2012, 206(5), 765-769.
287. DeChristopher, Brian A.; Fan, Alice C.; Felsher, Dean W.; Wender, Paul A. “‘Picolog,’ a Synthetically-Available Bryostatin Analog, Inhibits Growth of MYC-Induced Lymphoma In Vivo” Oncotarget 2012, 58-66.
286. Wender, Paul A.; Lesser, Adam B.; Sirois, Lauren E. “Rhodium Dinaphthocyclooctatetraene Complexes: Synthesis, Characterization and Catalytic Activity in [5+2] Cycloadditions” Angewandte Chemie Int. Ed. 2012, 51(11), 2736-2740.
285. Wender, Paul A. Editorial: “To Eun Lee om his 65th Birthday” Chem. Asian J. 2011, 6, 1900 – 1901 DOI: 10.1002/asia.201100574
284. Wender, Paul A.; Cooley, Christina B.; Geihe, Erika, I.; “Beyond Cell Penetrating Peptides: Designed Molecular Transporters” Drug Discovery Today: Technologies 2011, e49-e55
283. Paul A. Wender and Jenny Reuber “Function Oriented Synthesis: Preparation and Initial Biological Evaluation of New A-Ring Modified Bryologs” Tetrahedron 2011, 67, 9998-10005.
282. Paul A. Wender and Adam Schrier “Total Synthesis of Bryostatin 9” J. Am. Chem. Soc. 2011, 133, 9228-9231.
281. Adam Schrier, Brian Loy, and Paul A. Wender “Translating Nature’s Library: the Bryostatins and Function-Oriented Synthesis” Israel J. Chem. 2011, 51, 453-472
280. Wender, Paul A.; Jeremy L. Baryza, Stacey E. Brenner, Brian A. DeChristopher, Brian A. Loy, Adam J. Schrier, Vishal A. Verma ”Function-Oriented Synthesis: Design, Synthesis and Evaluation of Potent Bryostatin Analogs that Modulate PKC Translocation Selectivity“ Proc. Natl. Acad. Sci. USA 2011, 6721-6726.
279. Wender, Paul A.; Sirois, Lauren E.; Lesser, Adam B. “Rhodium-Catalyzed Intermolecular [5+2] Cycloaddition Reaction of 1-(2-Methoxy)-1-Vinylcyclopropane and N-Propargyl Phthalimide” Organic Syntheses 2011, 88, 109.
278. Wender, Paul A.; Buschmann, Nicole; Cardin, Nathan B.; Jones, Lisa R.; Kan, Cindy; Kee, Jung-Min; Kowalski, John A.; Longcore, Kate E. “Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities” Nature Chemistry 2011, 3, 615-619.
277. Wender, Paul A.; Sirois, Lauren E.; Stemmler, René T.; Williams, Travis J. “Highly Efficient, Facile, Room Temperature Intermolecular [5+2] Cycloadditions Catalyzed by Cationic Rhodium(I): One Step to Cycloheptenes and Their Libraries” Organic Lett. 2010, 1604-1607.
276. Wender, Paul A.; Longcore, Kate E. “Apoptolidins E and F, New Glycosyated Macrolactones Isolated from Nocardopsis sp.” Organic Lett. 2009, 5474-5477.
275. Liu, Peng; Sirois, Lauren E.; Cheong, Paul H.-Y.; Yu, Zhi-Xiang.; Hartung, Ingo, V.; Rieck, Heiko; Wender, Paul A.; Houk, Kendall N “Electronic and Steric Control of Regioselectivities in Rh(I)-Catalyzed (5+2) Cycloadditions: Experiment and Theory” J. Am. Chem. Soc. 2010, 10127-10135.
274. Paul A. Wender, René T. Stemmler, Lauren E. Sirois “A Metal-Catalyzed Intermolecular [5+2] Cycloaddition / Nazarov Cyclization Sequence and Cascade” J. Am. Chem. Soc. 2010, 2532-2533.
273. Christina B. Cooley, Brian M. Trantow, Fredrik Nederberg, Matthew K. Kiesewetter, James L. Hedrick, Robert M. Waymouth, Paul A. Wender “Oligocarbonate Molecular Transporters: Oligomerization Based Syntheses and Cell Penetrating Studies” J. Am. Chem. Soc. 2009, 16401-16403.
272. Wender, Paul; Croatt, Mitch; Kühn, Björn "Rhodium(I)-Catalyzed [2+2], [2+2+2], and [2+2+2+2] Cycloadditions of Dienes or Alkynes with a Bis-ene" Organometallics 2009, 28, 5841-5844.
271. Croatt, Mitchell P.; Wender, Paul A. “The Diene Effect: The Design, Development, and Mechanistic Investigation of Metal-Catalyzed Diene-yne, Diene-ene, and Diene-allene [2+2+1] Cycloaddition Reactions” Eur. J. Org. Chem. 2010, 19-32.
270. Lewis, Chad A.; Longcore, Kate E.; Miller, Scott J.; Wender, Paul A. “An Approach to the Site-Selective Diversification of Apoptolidin A with Peptide-Based Catalysts” Journal of Natural Products 2009, 72 (10), 1864-1869.
269. Shaha, S. P.; Tomic, J.; Shi, Y.; Pham, T.; Mero, P.; White, D.; He, L.; Baryza, J. L.; Wender, P. A.; Booth, J. W.; Spaner, D. E. “Prolonging Microtubule Dysruption Enhances the Immunogenicity of Chronic Lymphocytic Leukemia Cells” Clinical & Experimental Immunology 2009, 158, 186-198
268. Wender, Paul A.; Miller, Benjamin L. “Synthesis at the Molecular Frontier” Nature 2009, 460, 197-201.
267. Paul A. Wender,* Justin P. Christy, Adam B. Lesser, and Marc T. Gieseler “The Synthesis of Highly-Substituted Cyclooctatetraene Scaffolds by Metal-Catalyzed [2+2+2+2] Cycloadditions: Studies on Regioselectivity, Dynamic Properties and Metal Chelation” Angewandte Chemie Int. Ed 2009, 7687-7690.
266. Paul A. Wender and Daniel Strand “Cyclocarboamination of Alkynes with Aziridines: Synthesis of 2,3-Dihydropyrroles by a Catalyzed Formal [3+2] Cycloaddition” J. Am. Chem. Soc. 2009, 7528-7529.
265. Tapan Kumar Khan; Thomas J Nelson; Vishal A Verma; Paul A Wender; Daniel L Alkon: A Cellular Model of Alzheimer’s Disease Therapeutic Efficacy: PKC Activation Reverses A-beta induced biomarker Abnormality on Cultured Fibroblasts” Neurobiology of Disease 2009, 34, 332-339.
264. Stang, Stacey L.; Lopez-Campistrous, Ana; Song, Xiaohua; Dower, Nancy A.; Blumberg, Peter M.; Wender, Paul A.; Stone, Jim “A Pro-apoptotic Signaling Pathway involving RasGRP, Erk and Bim in B Cells” Experimental Hematology 2009, 37, 122-134.
263. Mooberry, Susan; Hilinski, Michael; Clark, Erin; and Wender, Paul “Function-Oriented Synthesis: Biological Evaluation of Laulimalide Analogues Derived from a Last Step Cross Metathesis Diversification Strategy” Molecular Pharmaceutics; 2008; 829-838.
262. Wender, Paul; DeChristopher, Brian; Schrier, Adam “Efficient Synthetic Access to a New Family of Highly Potent Bryostatin Analogues via a Prins-Driven Macrocyclization Strategy” J. Am. Chem. Soc. 2008, 6658-6659.
261. Wender, Paul A.; Verma, Vishal A. “The Design, Synthesis, and Evaluation of C7 Diversified Bryostatin Analogs Reveals a Hot Spot for PKC Affinity” Organic Lett. 2008, 3331-3334.
260. Dubikovskaya, Elena A.; Thorne, Steve H.; Pillow, Thomas H.; Contag, Christopher H.; Wender, Paul A. “Overcoming Multidrug Resistance of Small Molecule Therapeutics through Conjugation with Releasable Octaarginine Transporters” Proc. Natl. Acad. Sci. USA 2008, 12128-12133.
259. Paul A. Wender, Jung-Min Kee, and Jeffrey M. Warrington “Practical Synthesis of Prostratin, DPP, and Their Analogs, Adjuvant Leads Against Latent HIV” Science 2008, 649-652
258. E. A. Goun, H.-L. Lee, H. Hwang, A. N. Semyonov, H. Wang, L. R. Jones, R. J. Twieg, W. E. Moerner, P. A. Wender “Single-Molecule Motions of Oligoarginine Transporter Conjugates on the Plasma Membrane of CHO Cells” J. Am. Chem. Soc. 2008; 130; 9364-9370
257. Wender, Paul A.; Galliher, Wesley C.; Goun, Elena A.; Jones, Lisa R.: Pillow, Thomas H. “The design of guanidinium-rich transporters and their internalization mechanisms” Advanced Drug Delivery Reviews, 2008, 452-472.
256. Wender, Paul A.; Christy, Justin P. “Nickel(0)-Catalyzed [2+2+2+2] Cycloadditions of Terminal Diynes for the Synthesis of Substituted Cyclooctatetraenes” J. Am. Chem. Soc. 2007, 129(44), 13402-13403.
255. Zhi-Xiang Yu, Paul Ha-Yeon Cheong, Peng Liu, Claude Y. Legault, Paul A. Wender, K. N. Houk “Origins of Differences in Reactivities of Alkenes, Alkynes, and Allenes in [Rh(CO)2Cl]2-Catalyzed (5+2) Cycloaddition Reactions with Vinylcyclopropanes” J. Am. Chem. Soc. 2008, 130(8), 2378-2379
254. Peng Liu, Paul Ha-Yeon Cheong, Zhi-Xiang Yu, Paul A. Wender, K. N. Houk “Origins of Substituent effects on Reactivities of Vinylcyclopropanes in Rh(I)-Catalyzed (5+2) Cycloadditions” Angewandte Chemie Int. Ed 2008, 47, 3939-3941
253. Zhi-Xiang Yu, Paul Ha-Yeon Cheong, Peng Liu, Claude Y. Legault, Paul A. Wender, K. N. Houk “Origins of Differences in Reactivities of Alkenes, Alkynes, and Allenes in [Rh(CO)2Cl]2-Catalyzed (5+2) Cycloaddition Reactions with Vinylcyclopropanes” J. Am. Chem. Soc. 2008, 130(8), 2378-2379.
252. Wender, Paul A.; Verma, Vishal A.; Paxton, Thomas J.; Pillow, Thomas H. “Function Oriented Synthesis, Step Economy, and Drug Design” Accts. Chem. Res. 2008, 40-49.
251. Fernando J. Gómez, Nahrain E. Kamber, Nicole M. Deschamps, Adam P. Cole, Paul A. Wender, Robert M. Waymouth “N-Alkoxyimidazolylidene transition metal complexes: Application to [5+2] and [4+2] cycloaddition reactions” Organometallics 2007, 26, 4541-4545
250. Yuanyuan Wang, Jingxin Wang, Jiachun Su, Feng Huang, Lei Jiao, Yong Liang, Dazhi Yang,
Shiwei Zhang, Paul A. Wender, and Zhi-Xiang Yu “A Computationally Designed Rh(I)-Catalyzed Two-Component [5 + 2 + 1] Cycloaddition of Ene-Vinylcyclopropanes and CO for the Synthesis of Cyclooctenones” J. Am. Chem. Soc. 2007, 129, 10060-10061.
249. Wender, P. A.; D'Angelo, N.; Elitzin, V. I.; Ernst, M.; Jackson-Ugueto, E. E.; Kowalski, J. A.; McKendry, S.; Rehfeuter, M.; Sun, R.; Voigtlaender, D. “Function-Oriented Synthesis: Studies Aimed at the Synthesis and Mode of Action of 1-Alkyldaphnane Analogues” Org. Lett. 2007, 1829-1832
248. Wender, Paul A.; Longcore, Kate E. “Isolation, Structure Determination, and Anti-Cancer Activity of Apoptolidin D” Organic Lett. 2007 691-694.
247. Wender, Paul A.; Baryza, Jeremy L.; Hilinski, Michael K.; Horan, Joshua C.; Kan, Cindy; Verma, Vishal A. “Beyond Natural Products: Synthetic Analogues of Bryostatin 1” in Drug Discovery Research, Ziwei Huang Ed. 2007, 127-162.
246. Wender, Paul A.; Elena A. Goun, Lisa R. Jones, Thomas H. Pillow, Jonathan B. Rothbard, Rajesh Shinde, and Christopher H. Contag “Real-time Analysis of Uptake and Bioactivatable Cleavage of Luciferin-Transporter Conjugates in Transgenic Reporter Mice” Proc. Natl. Acad. Sci. USA 2007, 104, 10340-10345.
245. Wender, Paul A.; Bi, Christopher F.; Buschmann, Nicole; Gosselin, Francis; Kan, Cindy; Kee, Jung-Min; Ohmura, Hirofumi; “Studies on Oxidopyrylium [5+2] Cycloadditions: Towards a General Synthetic Route to the C12-Hydroxy Daphnetoxins” Organic Lett. 2006 8(23), 5373-5376
244. Wender, Paul A.; Horan, Joshua C.; Verma, Vishal A. “Total Synthesis and Initial Biological Evaluation of New B-Ring Modified Bryostatin Analogs” Organic Lett. 2006, 8(23), 5299-5302.
243. Wender, Paul A.; Paxton, Thomas J.; Williams, Travis J. “Cyclopentadienone Synthesis by Rhodium(I)-Catalyzed [3+2] Cycloaddition Reactions of Cyclopropenones and Alkynes” J. Am. Chem. Soc. 2006, 128(46), 14814-14815.
242. Wender, Paul A.; Horan, Joshua C. “The Synthesis and PKC Binding of a New Class of A-ring Diversifiable Bryostatin Analogs Utilizing a Double Asymmetric Hydrogenation and Cross-coupling Strategy” Organic Lett. 2006, 4581-4584.
241. Wender, P.A.; Hilinski, M. K.; Skaanderup, P.; and Soldermann, N. “Pharmacophore Mapping in the Laulimalide Series: Total Synthesis of a Vinylogue for a Late Stage Metathesis Diversification Strategy” Organic Lett. 2006, 4105-4108.
240. Elena A. Goun, Thomas H. Pillow, Lisa R. Jones, Jonathan B. Rothbard, Paul A. Wender “Molecular Transporters: Synthesis of Oligoguanidinium Transporters and Their Application to Drug Delivery and Real-Time Imaging” ChemBioChem 2006 1497-1515.
239. Paul Wender, Nicole M. Deschamps, Robert Sun "Rh(I)-Catalyzed C-C Bond Activation: Seven-Membered Ring Synthesis by a [6+1] Carbonylative Ring Expansion Reaction of Allenylcyclobutanes " Angewandte Chemie Int. Ed., 2006, 45(24), 3957-3960.
238. Wender, Paul A.; Croatt, Mitch P.; Witulski, Bernhard “New Reactions and Step Economy: The Total Synthesis of (±)-Salsolene Oxide Based on the Type II Transition Metal-Catalyzed Intramolecular [4+4] Cycloaddition” Tetrahedron 2006, 62, 7505-7511.
237. Paul A. Wender and Vishal A. Verma “Design, Synthesis, and Biological Evaluation of a Potent, PKC Selective, B-Ring Analog of Bryostatin” Organic Lett. 2006, 1893-1896.
236. Paul A. Wender, Justin P. Christy “Rhodium(I)-Catalyzed [4+2+2] Cycloadditions of Dienes, Alkenes, and Alkynes for the Synthesis of Cyclooctadienes” J. Am. Chem. Soc. 2006, 128(16), 5354-5355.
235. Paul A. Wender,* Michael K. Hilinski, Nicolas Soldermann, Susan Mooberry “Total Synthesis and Biological Evaluation of 11-Desmethyl Laulimalide, a Highly Potent Simplified Laulimalide Analog” Organic Lett. 2006, 1507-1510.
234. Paul Wender, Mitchell P. Croatt, Nicole M. Deschamps "Metal-Catalyzed [2+2+1] Cycloadditions of 1,3-Dienes, Allenes, and CO" Angewandte Chemie Int. Ed., 2006, 45(15), 2459-2462.
233. Paul A. Wender,* Lars O. Haustedt, Jaehong Lim, Jennifer A. Love, Travis J. Williams, and Joo-Yong Yoon “Asymmetric Catalysis of the [5+2] Cycloaddition Reaction of Vinylcyclopropanes and pi-Systems” J. Am. Chem. Soc. 2006, 128(19), 6302-6303
232. Lisa R. Jones, Elena A. Goun, Rajesh Shinde, Jonathan B. Rothbard, Christopher H. Contag, Paul A. Wender* “Releasable Luciferin-Transporter Conjugates: Tools for the Real Time Analysis of Cellular Uptake and Release” J. Am. Chem. Soc. 2006, 128(20), 6526-6527
231. Elena Goun, Rajesh Shinde, Karen Dehnert, Angie Adams-Bond, Paul Wender, Chris H. Contag, Benjamin L. Franc “Intracellular Cargo Delivery by an Octaarginine Transporter Adapted to Target Prostrate Cancer Cells Though Cell Surface Protease Activation” Bioconjugate Chem. 2006, 17(3), 787-796.
230. Wender, Paul A.; Croatt, Mitch P.; Deschamps, Nicole M. in Comprehensive Organometallic Chemistry III, “C-C Bond Formation (Part 1) by Addition Reaction: Higher-Order Cycloadditions” [Review Chapter], Iwao Ojima (Ed.), Elsevier Ltd. 2007, Vol 10, 603-648
229. Rothbard, Jonathan B.; Jessop, Theodore C.; Wender, Paul A. “Molecular Understanding of Cellular Uptake by Arginine-Rich Cell Penetrating Peptides” Polymeric Drug Delivery l (ACS Symposium Series 923), Chapter 12, 166-181, 2006.
228. Erin A. Clark, Bradley S. Davidson, Paul A. Wender, Susan L. Mooberry “Laulimalide and Synthetic Laulimalide Analogs are Synergistic with Paclitaxel and 2-Methoxyestradiol” Molecular Pharmaceutics 2006, 457-467.
227. Alexander V. Statsuk, Ruoli Bai, Jeremy L. Baryza, Vishal A. Verma, Ernest Hamel, Paul A. Wender, Sergey A. Kozmin “Actin is the Primary Cellular Receptor of Bistramide A” Nature Chemical Biology 2005, 383-388.
226. Wender, Paul A.; Kreider, Erik; Pelkey, Erin T.; Rothbard, Jonathan; VanDeusen, Christopher L. “Dendrimer Molecular Transporters: Synthesis and Evaluation of Tunable Polyguanidino Dendrimers that Facilitate Cellular Uptake” Organic Lett. 2005, 4815-4818.
225. Wender, Paul A.; Jankowski, Orion D.; Longcore, Kate; Tabet, Elie A.; Seto, Haruo; Tomikawa, Taijiro “Correlation of F0F1-ATPase Inhibition and Antiproliferative Activity of Apoptolidin Analogs” Organic Lett. 2006, 8(4), 589-592
224. Wender, Paul A.; Sukopp, Martin; Longcore, Kate "Apoptolidins B and C: Isolation, Structure Determination, and Biological Activity” Organic Lett. 2005, 7(6), 3025-3028.
223. Wender, Paul A.; Gamber, Gabriel G.; Williams, Travis J.; Rhodium(I)-Catalyzed [4+2], [5+2], and [5+2+1] Cycloadditions: New Reactions for Organic Synthesis in “Modern Rhodium-Catalyzed Organic Reactions” P. Andrew Evans Ed. Wiley-VCH Verlag Gmbh & Co. KgaA, Weinheim pp 263-299, 2005.
222. Wender, Paul A.; Clarke, Michael O.; Horan, Joshua C. “The Role of the A-Ring of Bryostatin Analogs in PKC Binding: Synthesis and Initial Biological Evaluation of New A-Ring Modified Bryologs” Organic Lett. 2005, 7(10), 1995-1998.
221. Wender, Paul A.; Baryza, Jeremy L. “Identification of a Tunable Site in Bryostatin Analogs: C20 Bryologs through Late Stage Diversification” Organic Lett. 2005, 7(6), 1177-1180.
220. Wender, P. A.; Gamber, G. G.; Hubbard, R. D.; Pham, S. M.; Zhang, L.; “Multicomponent Cycloadditions: The Four-Component [5+1+2+1] Cycloaddition of Vinylcyclopropanes, Alkynes, and CO” J. Am. Chem. Soc. 2005, 2836-2837.
219. Stone, James C.; Stang, Stacey L.; Zheng, Yong; Dower, Nancy A.; Brenner, Stacey E.; Baryza, Jeremy L.; Wender, Paul A. “Synthetic Bryostatin Analogues Activate the RasGRP1 Signaling Pathway” J. Med. Chem. 2004, 47, 6638-6644.
218. Wender, Paul A.; Deschamps, Nicole M.; Sun, Robert “Rh(I)-Catalyzed Cleavage of Unactivated C-O Bonds: Carbonylative Rearrangements Reactions of Allenyl Ethers to 2-Carboalkoxy-1,3-dienes” Canad. J. Chem. 2005, 838-842.
217. Jonathan B. Rothbard, Theodore C. Jessop, Paul A. Wender “Adaptive translocation: the role of hydrogen bonding and membrane potential in the uptake of guanidinium-rich transporters into cells” Advanced Drug Delivery Reviews, 2005, 57(4), 495-504
216. Hermann Wegner, Armin de Meijere, Paul Wender “Transition Metal-Catalyzed Intermolecular [5+2] and [5+2+1] Cycloadditions of Allenes and Vinylcyclopropanes” J. Am. Chem. Soc. 2005, 127(18), 6530-6531.
215. Wender, Paul A.; Hilinski, Michael; Mayweg, Alexander “Late Stage Intermolecular CH Activation for Lead Diversification: A Highly Chemoselective Oxyfunctionalization of the C-9 Position of Potent Bryostatin Analogues” Organic Lett. 2005, 79-82.
214. Caitlin Hammond, Yonghong Shi, Jenny Mena, Yelena Tomic, David Cervi, Liwei He, Amanda E. Millar, Mark DeBenedette, Andre C. Schuh, Jeremy L. Baryza, Paul A. Wender, Laszlo Radvanyi, and David E. Spaner “Effect of serum and anti-oxidants on the immunogenicity of protein kinase C-activated chronic lymphocytic leukemia cells” J. Immunotherapy, 2005, 28, 28-39.
213. Jonathan B. Rothbard Theodore C. Jessop, Richard S. Lewis, Bryce A. Murray, Paul A. Wender “The Role of Membrane Potential and Hydrogen Bonding in the Mechanism of Translocation of Guanidinium-Rich Peptides into Cells” J. Am. Chem. Soc. 2004, 9506-9507
212. Nadine Wong Shi Kam, Theodore C. Jessop, Paul A. Wender, Hongjie Dai “Nanotube Molecular Transporters: Internalization of Carbon Nanotube-Protein Conjugates into Mammalian Cells” J. Am. Chem. Soc. 2004, 126, 6850-6851.
211. Zhi-Xiang Yu, Paul A. Wender, K. N. Houk “On the Mechanism of [Rh(CO)2Cl]2 Catalyzed Intermolecular [5+2] Reactions Between Vinylcyclopropanes and Alkynes” J. Am. Chem. Soc. 2004, 126, 9154-9155.
210. Jeremy L. Baryza, Stacey E. Brenner, Madeleine L. Craske, Tobias Meyer, Paul A. Wender “Simplified Analogs of Bryostatin with Anti-Cancer Activity Display Greater Potency for Translocation of PKCdelta-GFP” Chemistry & Biology 2004, 11, 1261-1267.
209. Paul A. Wender, Nicole M. Deschamps, and Travis J. Williams “The Intermolecular Dienyl Pauson–Khand Reaction” Angewandte Chemie Int. Ed 2004, 43, 3076-3079.
208. Paul A. Wender, Mitchell P. Croatt, Nicole M. Deschamps, “Rhodium (I) Catalyzed [2+2+1] Cycloadditions of 1,3-Dienes, Alkenes, and CO” J. Am. Chem. Soc. 2004, 126, 5948-5949.
207. Susan L. Mooberry, Deborah A. Randall-Hlubek, Rachel M. Leal, Sayee G. Hegde, Robert D. Hubbard, Lei Zhang and Paul A. Wender “Structure-Function Studies on a New Class of Microtubule Stabilizing Agents Based on Laulimalide” Proc. Natl. Acad. Sci. USA 2004, 101, 8803-8808.
206. Wender, Paul A.; Baryza, Jeremy L.; Brenner, Stacey E.; Clarke, Michael O.; Craske, Madeleine L.; Horan, Joshua C.; Meyer, Tobias “Function Oriented Synthesis: The Design, Synthesis, PKC Binding and Translocation Activity of a New Bryostatin Analogue” Current Drug Discovery Technologies 2004, 1, 1-11.
205. Paul A. Wender “Foreword” l’actualité chimique 2003, 7-8.
204. Jonathan Rothbard, Paul Wender, Richard Lewis “Transepithelial delivery of therapeutics mediated by polyguanidyl compounds” Polym. Mater. Sci. Eng. 2003, 89, 108.
203. B. U. Samuel, B. Hearn, D. Mack, P. Wender, J. Rothbard, M. J. Kirisits, E. Mui, S. Wernimont, C. W. Roberts, S. P. Muench, D. W. Rice, S. T. Prigge, A. B. Law, and R. McLeod “Delivery of Antimicrobials into Parasites” Proc. Natl. Acad. Sci. USA , 2003, 100, 14281-14286
202. Wender, Paul A.; Jeon, Raok “Photoinduced cleavage of DNA by bromofluoroacetophenone-pyrrolecarboxamide conjugates” Bioorg. Med. Chem. Lett. 2003, 13(10), 1763-1766.
201. Benjamin L. Franc, Stefanie J. Mandl, Zurab Siprashvili, Paul A. Wender, Christopher H. Contag “Breaching Biological Barriers: Protein Translocation Domains as Tools for Molecular Imaging and Therapy” Mol Imaging. 2003, 2(4):313-323
200. Paul A. Wender, Michael F. T. Koehler, Martin Sendzik “A New Synthetic Approach to the C Ring of Known as well as Novel Bryostatin Analogues” Organic Lett. 2003, 5 (24), 4549-4552.
199. Paul A. Wender, Sayee Hegde, Robert Hubbard, Lei Zhang and Susan L. Mooberry “Synthesis and Biological Evaluation of (-)-Laulimalide Analogues” Organic Lett. 2003, 5(19), 3507-3509.
198. Thorsten A. Kirschberg, Chris L. VanDeusen, Jonathan B. Rothbard, Michael Yang, Paul A. Wender “Arginine-Based Molecular Transporters: The Synthesis and Chemical Evaluation of Releasable Taxol-Transporter Conjugates” Organic Lett. 2003, 5(19), 3459-3462.
197. Siprashvili, Zurab; Scholl, Florence A.; Oliver, Steven F.; Adams, Angie; Contag, Christopher H.; Wender, Paul A.; Khavari, Paul A. “Gene Transfer via Reversible Plasmid Condensation with Cysteine-Flanked, Internally Spaced Arginine-Rich Peptides (CFIS-R)” Human Gene Therapy, 2003, 14, 1225-1233.
196. Wender, P. A.; Jankowski, O. D.; Tabet, E. A.; Seto, H. “Facile Synthetic Access to and Biological Evaluation of the Macrocyclic Core of Apoptolidin” Org. Lett., 2003, 5, 2299-2302.
195. Lee R. Wright, Jonathan B. Rothbard, Paul A. Wender “Guanidinium Rich Peptide Transporters and Drug Delivery” Current Protein and Peptide Science, 2003, 4, 105-124.
194. Paul A. Wender, Nicole M. Deschamps, Gabriel G. Gamber “The Dienyl Pauson-Khand Reaction” Angewandte Chemie Int. Ed., 2003, 1853-1857.
93. Paul A. Wender, Jennifer A. Love, Travis J. Williams “Rhodium-Catalyzed [5+2] Cycloaddition Reactions in Water” Synlett. 2003, 1295-1298.
192. Paul A. Wender,* Jeremy L. Baryza, Stacey E. Brenner, Michael O. Clarke, Gabriel G. Gamber, Joshua C. Horan, Theodore C. Jessop, Cindy Kan, Kanaka Pattabiraman, and Travis J. Williams “Inspirations from Nature: New Reactions, New Therapeutic Leads, and New Drug Delivery Systems” Pure Appl. Chem. 2003, 75, 143-156.
191. Wender, P. A.; Jankowski, O. D.; Tabet, E. A.; Seto, H. “Toward a Structure-Activity Relationship for Apoptolidin: selective Functionalization of the Hydroxyl Group Array” Org. Lett. 2003, 487-490.
190. Wender, P. A.; Mayweg, Alexander V. W.; VanDeusen, Christopher L. “A Concise, Selective Synthesis of the Polyketide Spacer Domain of a Potent Bryostatin Analog” Organic Letters, 2003, 277-279.
189. Wender, P. A.; D’Angelo, N. “A Facile C-C bond cleavage in epoxides and its use for the synthesis of oxygenated heterocycles by a ring expansion strategy” ChemTracts 2002, 15, 183-188.
188. Wender, P. A.; Pedersen, T. M.; Scanio, M. J. C. “Transition Metal-Catalyzed Hetero-[5 + 2] Cycloadditions of Cyclopropyl Imines and Alkynes: Hydroazepines from Simple, Readily Available Starting Materials” J. Am. Chem. Soc.; 2002, 15154-15155.
187. Wender, P. A.; Williams, T. "[(Arene)Rh(COD)]+ Complexes as Catalysts for [5+2] Cycloadditions” Angewandte Chemie Int. Ed., 2002, 4550-4553
186. Wender, P. A.; Gulledge, A. V.; Jankowski, O. D.; Seto, H. “Isoapoptolidin: Structure and Activity of the Ring-Expanded Isomer of Apoptolidin” Organic Letters, 2002, 4, 3819-3822
185. Wender, P. A.; Baryza, J.; Bennett, C.; Bi, C.; Brenner, S. E.; Clarke, M.; Horan, J.; Kan, C.; Lacote, E.; Lippa, Nell, P.; Turner, T. “The Practical Synthesis of a Novel and Highly Potent Analog of Bryostatin” J. Am. Chem. Soc.; 2002, 124, 13648-13649.
184. Wender, P. A.; Rothbard, J. B.; Jessop, T. C.; Kreider, E. L.; Wylie, B. L. "Oligocarbamate Molecular Transporters: Design, Synthesis, and Biological Evaluation of a New Class of Transporters for Drug Delivery" J. Am. Chem. Soc. 2002, 124, 13382-13383.
183. Jonathan B. Rothbard, Erik Kreider, Kanaka Pattabiraman, Erin T. Pelkey, Christopher L. VanDeusen, Lee Wright, Bryan L. Wylie, and Paul A. Wender "Arginine-Rich Molecular Transporters for Drugs: The Role of Backbone and Sidechain Variations on Cellular Uptake", In Cell-Penetrating Peptides: Processes and Applications, Ülo Langel, Ed.; CRC Press, Boca Raton, Fla, 141-160, 2002.
182. Jonathan B. Rothbard, Erik Kreider, Christopher L. VanDeusen, Lee Wright, Bryan L. Wylie, and Paul A. Wender "Arginine-Rich Molecular Transporters for Drug Delivery: The Role of Backbone Spacing in Cellular Uptake", J. Med. Chem. 2002, 45, 3612-3618
181. Wender, P. A.; Hegde, S. G.; Hubbard, R. D.; Zhang, L.; “Total Synthesis of (-)-Laulimalide,” J. Am. Chem. Soc.; 2002; 124(18); 4956-4957.
180. Wender, P. A.; Bi, F. C.; Gamber, G. G.; Gosselin, F.; Hubbard, R. D.; Scanio, M. J. C.; Sun, R.; Williams, T. J.; Zhang, L. "Toward the Ideal Synthesis. New Transition Metal-catalyzed Reactions Inspired by Novel Medicinal Leads," Pure Appl. Chem. 2002, 74, 25-31.
179. Paul B. Robbins, Steven F. Oliver, Shannon M. Sheu, Julia B. Goodnough, Paul A. Wender, Paul A. Khavari, "Peptide Delivery to Tissue via reversibly Linked Protein transduction Sequences" BioTechniques, 2002, 33, 190-194
178. Paul A. Wender, Gabriel G. Gamber, Robert D. Hubbard, Lei Zhang "Three Component Cycloadditions: The First Transition Metal-Catalyzed [5+2+1] Cycloaddition Reactions", J. Am. Chem. Soc, 2002, 2876-2877
177. Robbins PB, Rothbard JB, Sheu SM, Oliver SF, Goodnough JB, Wender PA and Khavari PA. Molecular transporters facilitate topical protein transduction into the skin. J Invest Dermatol 2001, 117, 549.
176. Wender, P. A.; Pattabiraman, K.; VanDeusen, C. L. "Cooperative chemical sensing with bis-tritylacetylenes: pinwheels receptors with metal ion recognition properties." Chemtracts 2001, 14(4), 186-189
175. Paul A. Wender, Theodore C. Jessop, Kanaka Pattabiraman, Erin T. Pelkey, Chris L. VanDeusen "An Efficient, Scalable Synthesis of the Molecular Transporter Octaarginine via a Segment Doubling Strategy" Organic Letters, 2001, 3(21), 3229-3232.
174. Paul A. Wender, Gabriel G. Gamber, Marc J. C. Scanio "Serial [5+2]/[4+2] Cycloadditions: Facile, Preparative, Multi-Component Syntheses of Polycyclic Compounds from Simple, Readily Available Starting Materials" Angewandte Chemie, 2001, 40, 3895-3897
173. Paul A. Wender, F. Christopher Bi, Michael A. Brodney, Francis Gosselin "Asymmetric Synthesis of the Tricyclic Core of NGF-Inducing Cyathane Diterpenes via a Transition Metal Catalyzed [5+2] Cycloaddition" Organic Letters 2001, 3 (13), 2105-2108
172. Mayumi Shindo, Kazuhiro Irie, Akifumi Nakahara, Hajime Ohigashi, Hiroaki Konishi, Ushio Kikkawa, Paul A. Wender "Toward the Identification of Selective Modulators of Protein Kinase C (PKC) Isozymes: Establishment of the Binding Assay for PKC Isozymes Using Synthetic C1 Peptide Receptors and Identification of the Critical Residues Involved in the Phorbol Ester Binding" Bioorganic and Medicinal Chemistry Letters , 2001, 9, 2073-2081.
171. Leon Chen, Lee R. Wright, Che-Hong Chen, Steven F. Oliver, Paul A. Wender, Daria Mochly-Rosen "Molecular Transporters for Peptides: Delivery of a Cardioprotective Epsilon PKC Agonist Peptide into Cells and Intact Ischemic Heart using an Oligoguanidine Transport System" Chemistry & Biology 2001, 8(12), 1123-1129.
170. Raok Jeon, Paul A. Wender "Photocleavage of DNA by 4'-Bromoacetophenone Analogs" Archives of Pharmacol. Research 2001, 24, 39-43.
169. Raok Jeon, Paul A. Wender "Design and Synthesis of new DNA Photocleavers: 4'-Bromoacetophenone-pyrrolecarboxamide Hybrid Compounds" Archives of Pharmacol. Research 2000, 23, 585-588.
168. Tanaka, M.; Irie, K.; Nakagawa, Y.; Nakamura, Y.; Ohigashi, H.; Wender, P. A. The C4 Hydroxyl Group of Phorbol Esters is not necessary for Protein Kinase C Binding Bioorganic and Medicinal Chemistry Letters, 2001, 11, 719-722.
167. Yu Nakagawa, Kazuhiro Irie, Hajime Ohigashi, Hideo Hayashi, Paul A. Wender "Synthesis and PKC Isozyme Surrogate Binding of Indothiolactam-V, A New Thioamide Analogue of Tumor Promoting Indolactam-V" Bioorganic and Medicinal Chemistry Letters, 2000, 10, 2087-2090.
166. Paul A. Wender, Dennis J. Mitchell, Kanaka Pattabiraman, Erin Pelkey, Lawrence Steinman, Jonathan B. Rothbard "Molecular Transporters: The Design, Synthesis, and Evaluation of Molecules that Enable or Enhance Cellular Uptake" Proc. Natl. Acad. Sci. USA, 2000, 97, 13003-13008.
165. Paul A. Wender, Claudia M. Barzilay, Alaric J. Dyckman The First Intermolecular Transition Metal-Catalyzed [5+2] Cycloadditions with Simple, Unactivated, Vinylcyclopropanes. J. Am. Chem. Soc. 2001, 123, 179-180.
164. Kazuhiro Irie, Akifumi Nakahara, Yasuyuki Ikawa, Minoru Tanaka, Yu Nakagawa, Yoshimasa Nakamura, Hajime Ohigashi, and Paul A. Wender Synthesis and Tumor-promoting Activities of 12-Epi-phorbol-12,13-dibutyrate, Biosci. Biotechnol. Biochem. 2000, 64, 2429-2436.
163. Paul A. Wender, Lei Zhang, The Asymmetric Total Synthesis of (+)-Aphanamol I based on the Transition Metal Catalyzed [5+2] Cycloaddition of Allenes Vinylcyclopropanes, Organic Lett. 2000, 2323-2326.
162. Jonathan B. Rothbard, Sarah Garlington, Qun Lin, Thorsten Kirschberg, Erik Kreider, P. Leo McGrane, Paul A. Wender and Paul A. Khavari, Conjugation of Arginine Oligomers to Cyclosporin A Facilitates Topical Delivery and Inhibition of Inflammation, Nature Medicine 2000, 6, 1253-1257.
161. Paul A. Wender, Arlene G. Correa, Yoshihiro Sato, Robert Sun "Transition Metal-Catalyzed [6+2] Cycloadditions of 2-Vinylcyclobutanones and Alkenes: A new Reaction for the Synthesis of Eight-Membered Rings" J. Am. Chem. Soc. 2000, 122, 7815-7816.
160. Paul A. Wender, Alaric J. Dyckman, Craig O. Husfeld, Marc J. C. Scanio "A New and Practical Five-carbon Component for Metal-Catalyzed [5+2] Cycloadditions: Preparative Scale Syntheses of Substitutes Cycloheptenones" Org. Lett. 2000, 2, 1609-1611.
159. Paul A. Wender and Alaric J. Dyckman “Transition Metal-Catalyzed [5+2] Cycloadditions of 2-Substituted-1-vinylcyclopropanes: Catalyst Control and Reversal of Regioselectivity,” Organic Letters, 1999, 1, 2089.
158. Paul A. Wender and Raok Jeon, “Bromoacetophenone-Based Photonucleases: Photoinduced Cleavage of DNA by 4'-Bromoacetophenone-Pyrrolecarboxamide Conjugates,” Organic Letters, 1999, 1, 2117.
157. Paul A. Wender, Alaric J. Dyckman, Craig O. Husfeld, Dieter Kadereit, Jennifer A. Love, and Heiko Rieck, “Transition Metal-Catalyzed [5+2] Cycloadditions with Substituted Cyclopropanes: First Studies of Regio- and Stereoselectivity,” J. Am. Chem. Soc., 1999, 121, 10442.
156. Hiroyuki Fukuda, Kazuhiro Irie, Akifumi Nakahara, Hajime Ohigashi and Paul A. Wender, “Solid-phase Synthesis, Mass Spectrometric Analysis of the Zinc-folding, and Phorbol Ester-binding Studies of the 116-mer Peptide Containing the Tandem Cysteine-rich C1 Domains of Protein Kinase C Gamma, Bioorganic and Medicinal Chemistry Letters, 1999, 7, 1213.
155. Paul A. Wender and Blaise Lippa, “Synthesis and Biological Evaluation of Bryostatin Analogues: The Role of the A-Ring,” Tetrahedron Lett, 2000, 41, 1007-1011.
154. Paul A. Wender, Thorsten Kirschberg, Peter D. Williams, Harold M. M. Bastiaans, and Kazuhiro Irie, "A New Class of Simplified Phorbol Ester Analogs: Synthesis and Binding to PKC and h-C1B (hPKC-CRD2)," Organic Letters, 1999, 1, 1009.
153. Kazuhiro Irie, Akifumi Nakahara, Hajime Ohigashi, Hiroyuki Fukuda, Paul A. Wender, Hiroaki Konishi, and Ushio Kikkawa, “Synthesis and Phorbol Ester-Binding Studies of the Individual Cysteine-Rich Motifs of Protein Kinase D,” Bioorganic and Medicinal Chemistry Letters 1999, 9, 2487.
152. Paul A. Wender and Kevin W. Hinkle, “Synthesis and Biological Evaluation of a New Class of Bryostatin Analogues: The Role of the C20 Substituent in Protein Kinase C. Binding,” Tetrahedron Lett,, 2000, 41, 6725-6729.
151. Paul A. Wender, Masahiro Fuji, Craig O. Husfeld, and Jennifer A. Love, “Rhodium-Catalyzed [5+2] Cycloadditions of Allenes and Vinylcyclopropanes: Asymmetric Total Synthesis of (+)-Dictamnol, Organic Letters, 1, 137 (1999).
150. Paul A. Wender, Michael F. T. Koehler, D. L. Wright, and K. Irie, “Mapping Phorbol Ester Binding Domains: The Design, Synthesis and Protein Kinase C Binding Assay of Novel Phorbol Dimers,” Synthesis, SI, 1401 (1999).
149. Paul A. Wender, Kevin W. Hinkle, Michael F. T. Koehler and Blaise Lippa, “The Rational Design of Potential Chemotherapeutic Agents: Synthesis of Bryostatin Analogues,” Medicinal Research Reviews, 19, 388 (1999).
148. Kazuhiro Irie, Kentaro Oie, Akifumi Nakahara, Yoshiaki Yanai, Hajime Ohigashi, Hiroyuki Fukuda and Paul A. Wender, “Synthesis and Phorbol Ester Binding of the Zinc-finger Like Sequences of All Protein Kinase C Isozymes, In Peptide Science 1998, M. Kondo, Ed.: Protein Research Foundation, Osaka , 65-68 (1999).
147. Paul A. Wender and Jennifer A. Love, "The Synthesis of Seven-Membered Rings: General Strategies and the Design and Development of a New Class of Cycloaddition Reactions," In Advances in Cycloaddition, Harmata, Michael, Ed.; JAI Press, Stamford, Connecticut, 1-45 (1999).
146. Paul A. Wender, Blaise Lippa, Cheol-Min Park, Kazuhiro Irie, Akifumi Nakahara, and Hajime Ohigashi, “Selective Binding of Bryostatin Analogues to the Cysteine Rich Domains of Protein Kinase C Isozymes,” Bioorganic and Medicinal Chemistry Letters, 9, 1687 (1999).
145. Paul A. Wender, Frank Glorius, Craig O. Husfeld, Elke Langkopf, Jennifer A. Love, “Transition Metal-Catalyzed [5+2] Cycloadditions of Allenes and Vinylcyclopropanes: First Studies of Endo-Exo Selectivity, Chemoselectivity, Relative Stereochemistry, and Chirality Transfer,” J. Am. Chem. Soc, 121, 5348 (1999).
144. Hiroyuki Fukuda, Kazuhiro Irie, Akifumi Nakahara, Kentaro Oie, Hajime Ohigashi, and Paul A. Wender, “Synthesis and Binding Studies of the 116-mer Peptide Containing the Double Cystein-rich Motifs of Protein Kinase C gamma,” Tetrahedron Lett, 39, 7943, (1998).
143. Paul A. Wender and Jennifer A. Love, Condensation and Commentary on: "Organic Synthesis Delivers on Another Medicinal Lead: Total Syntheses of Dysidiolide,” CHEMTRACTS--ORGANIC CHEMISTRY, 12, 512 (1999).
142. Paul A. Wender, Jef De Brabander, Patrick G. Harran, Kevin W. Hinkle, and Blaise Lippa, “Synthesis and Biological Evaluation of Fully Synthetic Bryostatin Analogues, Tetrahedron Lett., 39, 8625 (1998).
141. Paul A. Wender, Yolanda Martin-Cantalejo, Andrew J. Carpenter, Anna Chiu, Jef De Brabander, Patrick G. Harran, Juan-Miguel Jimenez, Michael F. T. Koehler, Blaise Lippa, James A. Morrison, Stephan G. Müller, Stephan N. Müller, Cheol-Min Park, Makoto Shiozaki, Carsten Siedenbiedel, Donald J. Skalitzky, Masahiro Tanaka, and Kazuhiro Irie, “The Chemistry-Medicine Continuum: Synthetic, Computer, Spectroscopic and Biological Studies on New Chemotherapeutic Leads,” Pure & Appl. Chem, 70, 539, (1998).
140. Paul A. Wender and Timothy M. Dore, “A Formal Synthesis of Crinipellin B Based on the Arene-Alkene meta-Photocycloaddition Reaction,” Tetrahedron Lett., 39, 8589 (1998).
139. Kazuhiro Irie, Kentaro Oie, Akifumi Nakahara, Yoshiaki Yanai, Hajime Ohigashi, Paul A. Wender, Hiroyuki Fukuda, Hiroaki Konishi and Ushio Kikkawa, “Molecular Basis for Protein Kinase C (PKC) Isozyme Selective Binding: The Synthesis, Folding, and Phorbol Ester Binding of the Cysteine-Rich C1 Domains of All PKC Isozymes, J. Am. Chem. Soc, 120, 9159 (1998).
138. Paul A. Wender, Heiko Rieck, Masahiro Fuji, “The Transition Metal-Catalyzed Intermolecular [5+2] Cycloaddition: The Homologous Diels-Alder Reaction, J. Am. Chem. Soc, 120, 10976 (1998).
137. Paul A. Wender and David Sperandio, “A New and Selective Catalyst for the [5+2] Cycloaddition of Vinylcyclopropanes and Alkynes,” J. Org. Chem, 63, 4164 (1998).
136. Paul A. Wender, Craig O. Husfeld, Elke Langkopf, Jennifer A. Love, Norbert Pleuss, “The First Metal-Catalyzed Intramolecular [5+2] Cycloadditions of Vinylcyclopropanes and Alkenes: Scope, Stereochemistry, and Asymmetric Catalysis,” Tetrahedron, 54, 7203 (1998).
135. Paul A. Wender and Timothy M. Dore, Condensation and Commentary on: "Radical Carboxylation: Ester Synthesis From Alkyl Iodides, Carbon Monoxide, and Alcohols Under Irradiation Conditions,” CHEMTRACTS--ORGANIC CHEMISTRY, 11, 268 (1998).
134. Paul A. Wender and Paul E. Floreancig, Condensation and Commentary on: "Total Synthesis of (")-Taxusin,” CHEMTRACTS--ORGANIC CHEMISTRY, 11, 16 (1998).
133. Kazuhiro Irie, Yoshiaki Yanai, Kentaro Oie, Junya Ishizawa, Yu Nakagawa, Hajime Ohihashi, Paul A. Wender and Ushio Kikkawa, “Comparison of Chemical Characteristics of the First and the Second Cysteine-Rich Domains of Protein Kinase Cg, ”Bioorganic & Medicinal Chemistry Lett., 5, 1725 (1997).
132. Paul A. Wender, Craig O. Husfeld, Elke Langkopf, Jennifer A. Love, "First Studies of the Transition Metal-Catalyzed [5+2] Cycloadditions of Alkenes and Vinylcyclopropanes: Scope and Stereochemistry,” J. Am. Chem. Soc., 120, 1940 (1998).
131. Paul A. Wender and Daesung Lee, Condensation and Commentary on: "Enantioselective Synthesis of Neocarzinostatin Chromophore Aglycon," CHEMTRACTS--ORGANIC CHEMISTRY, 10, 653 (1997).
130. Paul A. Wender, Dennis Wright, Scott Handy, "Toward the Ideal Synthesis," Chemistry & Industry, 19, 765 (1997).
129. Paul A. Wender, Thomas E. Smith, "Transition Metal-Catalyzed Intramolecular [4+2] Cycloadditions: Mechanistic and Synthetic Investigations, Tetrahedron, 54, 1255 (1998).
128. Paul A. Wender, Jef De Brabander, Patrick G. Harran, Juan-Miguel Jimenez, Michael F. T. Koehler, Blaise Lippa, Cheol-Min Park, Carsten Siedenbiedel, and George R. Pettit, "The Design, Computer Analysis, Solution Structure, and Biological Evaluation of the First Totally Synthetic Analogs of Bryostatin 1," Proc. Natl. Acad. Sci. USA , 95, 6624 (1998).
127. Paul A. Wender, Jef De Brabander, Patrick G. Harran, Juan-Miguel Jimenez, Michael F. T. Koehler, Blaise Lippa, Cheol-Min Park, and Makoto Shiozaki, "Synthesis of the First Members of a New Class of Biologically Active Bryostatin Analogs," J. Am. Chem. Soc., 120, 4534 (1998).
126. Paul A. Wender and Patrick G. Harran, Condensation and Commentary on: "Alkynylation of C-H Bonds Via Reaction with Acetylenic Triflones," CHEMTRACTS--ORGANIC CHEMISTRY, 10, 522 (1997).
125. Paul A. Wender, Cynthia D. Jesudason, Hiroyuki Nakahira, Norikazu Tamura, Anne Louise Tebbe, Yoshihide Ueno, "The First Synthesis of a Daphnane Diterpene: The Enantiocontrolled Total Synthesis of (+)-Resiniferatoxin," J. Am. Chem. Soc., 119, 12976 (1997).
124. Paul A. Wender, John Nuss, David B. Smith, Angel Suárez-Sobrino, Jan Vågberg, Debra Decosta, Jon Bordner, "Transition Metal Catalyzed Cycloadditions: An Intramolecular [4+4] Cycloaddition Strategy for the Efficient Synthesis of Dicyclopenta[a,d]cyclooctene {5-8-5) Ring Systems, J. Org. Chem, 62, 4908 (1997).
123. Sofia M. Touami, Clara C. Poon, and Paul A. Wender, "Sequence Specific DNA Cleavage By Conjugates of Benzotriazoles and Minor Groove Binders," J. Am. Chem. Soc., 119, 7611 (1997).
122. Kazuhiro Irie, Yoshiaki Yanai, Hajime Ohigashi and Paul A. Wender, "Synthesis and Characterization of Model Peptides Incorporating the Phorbol Ester-binding Domain of Protein Kinase C," Peptide Chemistry 1996: C. Kitada (Ed.), Protein Research Foundation, Osaka, 209 (1997).
121. Paul A. Wender, Daesung Lee, Tapan K. Lal, Susan B. Horwitz, and Srinivasa Rao, "Synthesis of Novel Taxol Analogs and Evaluation of their Biological Activities," Bioorg. & Med. Chem. Lett., 7, 1941 (1997).
120. Paul A. Wender, Alan W. White, and Frank E. McDonald, "Spiroannelation Via Organobis(cuprates): 9,9-Dimethylspiro[4.5]decan-7-one," In Organic Syntheses Coll. Vol. 9, p.350 (1998)
119. Paul A. Wender, Mitch A. deLong, Fred C. Wirecko “Novel Oxidative Rearrangement Product of the First trans, cis, cis, cis-[5.5.5.5]Fenestrane Derivative” Acta Cryst. 1997, C53, 954-956.
118. Paul A. Wender, Kenneth D. Rice, and Mark E. Schnute, "The First Formal Asymmetric Synthesis of Phorbol," J. Am. Chem. Soc., 119, 7897 (1997).
117. Yoshiaki Yanai, Kazuhiro Irie, Hajime Ohigashi, and Paul A. Wender, "Synthesis and Characterization of the First Cysteine-Rich Domain of Novel Protein Kinase C," Bioorganic & Medicinal Chemistry Lett., 7, 117 (1997).
116. Kazuhiro Irie, Yoshiaki Yanai, Kentaro Oie, Hajime Ohigashi, and Paul Wender, "Protein Kinase C Regulatory Domain Surrogate Peptides: Effects of Metal Ions on Folding, Phorbol Ester-binding, and Selectivity," Bioorganic & Medicinal Chemistry Lett., 7, 965 (1997).
115. Paul A. Wender, Neil F. Badham, Simon P. Conway, Paul E. Floreancig, Timothy E. Glass, Jonathan B. Houze, Nancy E. Krauss, Daesung Lee, Daniel G. Marquess, Paul L. McGrane, Wei Meng, Michael G. Natchus, Anthony J. Shuker, James C. Sutton, and Richard E. Taylor, "The Pinene Path to Taxanes. 6. A Concise Stereocontrolled Synthesis of Taxol," J. Am. Chem. Soc., 119, 2757 (1997).
114. Paul A. Wender, Neil F. Badham, Simon P. Conway, Paul E. Floreancig, Timothy E. Glass, Christian Gränicher, Jonathan B. Houze, Jan Jänichen, Daesung Lee, Daniel G. Marquess, Paul L. McGrane, Wei Meng, Thomas P. Mucciaro, Michel Mühlebach, Michael G. Natchus, Holger Paulsen, David B. Rawlins, Jeffrey Satkofsky, Anthony J. Shuker, James C. Sutton, Richard E. Taylor, and Katsuhiko Tomooka, "The Pinene Path to Taxanes, 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor," J. Am. Chem. Soc., 119, 2755 (1997).
113. Kazuhiro Irie, Tomomi Isaka, Yoriko Iwata, Yoshiaki Yanai, Yoshimasa Nakamura, Fumito Koizumi, Hajime Ohigashi, Paul A. Wender, Yoshiko Satomi, Hoyoku Nishino, "Synthesis and Biological Activities of New Conformationally Restricted Analogues of (-)-Indolactam-V: Elucidation of the Biologically Active Conformation of the Tumor-Promoting Teleocidins," J. Am. Chem. Soc., 118, 10733 (1996).
112. Paul A. Wender, Timothy E. Glass, Nancy E. Krauss, Michel Mühlebach, Bernd Peschke, David B. Rawlins, "The Pinene Path to Taxanes 4: Approaches to Taxol and Taxol Analogs Through Elaboration of Aromatic C-Ring Precursors," J. Org. Chem, 61, 7662 (1996).
111. Paul A. Wender, Timothy M. Dore, and Mitch A. deLong, "An Arene-Alkene Photocycloaddition-Radical Cyclization Cascade: The First Syntheses of cis,cis,cis,trans-[5,5,5,5]-fenestranes," Tetrahedron Lett, 37, 7687 (1996).
110. Paul A. Wender, Sofia M. Touami, Carole Alayrac, and Ulrich C. Philipp, "Triazole Photonucleases: A New Family of Light Activatable DNA Cleaving Agents," J. Am. Chem. Soc., 118, 6522 (1996).
109. Kazuhiro Irie, Yoshiaki Yanai, Hajime Ohigashi, Paul A. Wender, and Benjamin L. Miller, " Synthesis and Characterization of the Second Cysteine-Rich Region of Mouse Skin PKCh," Bioorganic & Medicinal Chemistry Lett, 6, 353 (1996).
108. Paul A. Wender, Thomas E. Smith, "Transition Metal-Catalyzed Intramolecular [4+2] Cycloadditions: A Novel Method for the Assembly of Nitrogen Heterocycles and Its Application to Yohimbane Alkaloid Synthesis," J. Org. Chem, 61, 824 (1996).
107. Paul A. Wender, Ludger A. Wessjohann, Bernd Peschke, and David B. Rawlins, "The Pinene Path to Taxol: Readily Accessible A-Ring Building Blocks Based on Novel Alkyl- and Alkenyllithium Reagents with Internal Carbonyl Groups," Tetrahedron Lett, 36, 7181 (1995).
106. Kazuhiro Irie, Takashi Ishii, Hajime Ohigashi, Paul A. Wender, Benjamin L. Miller and Naohito Takeda, "Synthesis and Characterization of New Photolabile Phorbol Esters for Affinity Labeling of Protein Kinase C.," J. Org. Chem., 61, 2164 (1996).
105. Paul A. Wender, "Introduction: Frontiers in Organic Synthesis," Chemical Reviews, 96, No. 1, Editorial (1996).
104. Kazuhiro Irie, Fumito Koizumi, Yoriko Iwata, Takashi Ishii, Yoshiaki Yanai, Yoshimasa Nakamura, Hajime Ohigashi and Paul A. Wender, "Synthesis and Biological Activities of New Conformationally Fixed Analogues of (-)-Indolactam-V, The Core Structure of Tumor-Promoting Teleocidins," Bioorganic & Medicinal Chemistry Lett , 5, 453 (1995).
103. Paul A. Wender, Paul E. Floreancig, Timothy E. Glass, Michael G. Natchus, Anthony J. Shuker and James C. Sutton, "Toward the Synthesis of Taxol and its Analogs: Incorporation of Non-Aromatic C-Rings in the Pinene Pathway," Tetrahedron Letters, 36, 4939 (1995).
102. Paul A. Wender, Timothy E. Glass, "The Pinene Approach to Taxanes 2: Development of a Versatile C9, C10 Linker," Synlett Special Issue, 516 (1995).
101. Paul A. Wender and Thomas E. Smith, "Transition Metal-Catalyzed Intramolecular [4+2] Cycloadditions: Initial Studies on Stereochemistry and on Steroid and Vitamin D Analog Syntheses," J. Org. Chem., 60, 2962 (1995).
100. Paul A. Wender, Hisashi Takahashi, and Bernhard Witulski, "Transition Metal Catalyzed [5+2] Cycloadditions of Vinylcyclopropanes and Alkynes: A Homolog of the Diels-Alder Reaction for the Synthesis of Seven-membered Rings," J. Am. Chem. Soc. 117, 4720 (1995).
99. Paul A. Wender, Suzanne Beckham, Jacqueline G. O'Leary, "A Second Generation Photochemically Activatable Dynemicin Analog: A Concise Synthesis and DNA Cleavage Studies," Synthesis, Special Issue, 1278 (1994).
98. Paul A. Wender, Thomas E. Jenkins, Shigeaki Suzuki, "Transition Metal Catalyzed Intramolecular [4+2] Diene-Allene Cycloadditions: A Convenient Synthesis of Angularly Substituted Ring Systems with Provision for Reagent-Based Regio- and Stereocomplementarity," J. Am. Chem. Soc., 117, 1843 (1995).
97. Paul A. Wender, Suzanne Beckham, and Debra L. Mohler, “The Intramolecular Addition of Silylated Alkynes to Aldehydes: Methodology for the Construction of Cyclic Enediynes and Its Application to Dynemicin Analogs," Tetrahedron Lett., 36, 209 (1995).
96. Paul A. Wender, et al., "The Pinene Path to Taxanes: Genesis and Evolution of a Synthesis Strategy," in ACS Symposium Series: Taxane Anticancer Agents: Basic Science and Current Status; G. Georg, T. T. Chan, I. Ojima, D. M. Vyas , Eds.; American Chemical Society, Series 583, pp. 326-339 (1995).
95. Paul A. Wender, Daniel G. Marquess, P. Leo McGrane and Richard E. Taylor, Condensation and Commentary on: "First Total Synthesis of Taxol. 1. Functionalization of the B Ring and First Total Synthesis of Taxol. 2. Completion of the C and D Ring" and "Total Synthesis of Taxol," CHEMTRACTS--ORGANIC CHEMISTRY, 7, 160 (1994).
94. Paul A. Wender, J. J. Howbert, T. M. Dore, "The Total Synthesis of (±)-a-Cedrene," In Photochemical Key Steps in Organic Synthesis; Mattay, J.; Griesbeck, A. G., Eds.; VCH Verlagsgesellschaft: Weinheim, Germany; 181-185 (1994).
93. Paul A. Wender, Michael G. Natchus, Anthony J. Shuker, "Toward the Total Synthesis of Taxol and Its Analogues," in Taxol: Science and Applications; Matthew Suffness, Ed.; CRC Press, Inc, London; pp. 123-187, (1995).
92. Paul A. Wender and Thomas E. Smith, nine entries including: "Bis(1,5-cyclooctadiene)nickel(0)," in Encyclopedia of Reagents for Organic Synthesis; Leo A. Paquette, Ed; John Wiley & Sons, Ltd, Chichester; pp. 450-457 (1995).
91. Paul A. Wender and Richard E. Taylor, Condensation and Commentary on: "A One-Step Synthesis of the Ciclamycin 0 Trisaccharide," CHEMTRACTS--ORGANIC CHEMISTRY, 6, 255 (1993).
90. Paul A. Wender, Kazuhiro Irie, and Benjamin L. Miller, "Identification, Activity, and Structural Studies of Peptides Incorporating the Phorbol Ester Binding Domain of Protein Kinase C," Proc. Natl. Acad. Sci. USA, 92, 239 (1995).
89. Paul A. Wender and Mark J. Tebbe, “The Synthesis and Chemistry of A Simplified, Functional Analogue of Neocarzinostatin Chromophore: Identification of an Intramolecular 1,5-Hydrogen Atom Transfer Relevant to the Mechanism and Cleavage Selectivity of Diyl-Based DNA Cleaving Agents,” Tetrahedron, 50, 1419 (1994).
88. Paul A. Wender, Charles K. Zercher, Suzanne Beckham and Eva-Marie Haubold, "A Photochemically Triggered DNA Cleaving Agent: Synthesis, Mechanistic and DNA Cleavage Studies on a New Analog of the Antitumor Antibiotic Dynemicin," J. Org. Chem., 58, 5867 (1993).
87. Paul A. Wender, Timothy M. Dore, "Intra-and Inter-Molecular Cycloadditions to Benzene Derivatives," In CRC Handbook of Organic Photochemistry and Photobiology, Horspool, William, Ed.; CRC Press, London, 280-290 (1995).
86. Paul A. Wender, Kazuhiro Irie, and Benjamin L. Miller, "Synthesis and Binding of Photoaffinity Ligand Candidates for Protein Kinase C," J. Org. Chem., 58, 4179 (1993).
85. Paul A. Wender, Alan W. White, and Frank E. McDonald, "Spiroannelation Via Organobis(cuprates): 9,9-Dimethylspiro[4.5]decan-7-one," In Organic Syntheses Coll. Organic Syntheses Vol. 70, p.204 (1992).
84. Paul A. Wender and David B. Rawlins, “Toward the Synthesis of Taxol C,D Ring System: Photolysis of a-Methoxy Ketones,” Tetrahedron, 48, 7033 (1992).
83. Paul A. Wender, Thomas P. Mucciaro, "A New and Practical Approach to the Synthesis of Taxol and Taxol Analogues: The Pinene Path," J. Am. Chem. Soc., 114, 5878 (1992).
82. Paul A. Wender, Benjamin L. Miller, "Toward the Ideal Synthesis: Connectivity Analysis and Multi-Bond Forming Processes," In Organic Synthesis: Theory & Applications, Vol 2; Hudlicky, Thomas, Ed.; JAI; Greenwich, CT; 27-66 (1993).
81. Paul A. Wender, Jose L. Mascareñas, "Preparation and Cycloadditions of a 4-Methoxy-3-Oxido-Pyrylium Ylid: A Reagent for the Synthesis of Highly Substituted Seven Membered Rings and Tetrahydrofurans," Tetrahedron Lett. 33, 2115 (1992).
80. Paul A. Wender, Mark Tebbe, "Nickel(0)-Catalyzed Intramolecular [4+4] Cycloadditions: 5. The Type II Reaction in the Synthesis of Bicyclo[5.3.1]undecadienes," Synthesis, 12, 1089 (1991).
79. Paul A. Wender, Jose L. Mascareñas, "Studies on Tumor Promoters. 11. A new [5+2] Cycloaddition Method and its Application to the Synthesis of BC Ring Precursors of Phorboids," J Org Chem, 56, 6267 (1991).
78. Paul A. Wender, Robert C. Kelly, Suzanne Beckham, and Benjamin L. Miller, "Studies on DNA-cleaving agents: Computer modeling analysis of the mechanism of activation and cleavage of dynemicin-oligonucleotide complexes," Proc. Natl. Acad. Sci. USA, 88, 8835 (1991).
77. Paul A. Wender, Mark J. Tebbe, "Studies on DNA Cleaving Agents: Synthesis and Chemically Induced Cycloaromatization of a Monocyclic Neocarzinostatin Chromophore Analogue." Tetrahedron Lett., 32, 4863 (1991).
76. Paul A. Wender, Cynthia M. Cribbs, "Structural Design in Anti-tumor Compounds." In Molecular Mechanisms and Their Clinical Applications in Malignancies; Bergsagel, Daniel E. and Mak, Tak W., Eds.; Academic ; San Diego, CA, 215 (1991).
75. Paul A. Wender, Cynthia M. Cribbs, "Computer Assisted Molecular Design Related to the Protein Kinase C Receptor," In Advances in Medicinal Chemistry; Maryanoff, C.A., Maryanoff, B.E., Eds.; JAI; Greenwich, CT; 1, 1-53 (1992).
74. Paul A. Wender, Janet Wisniewski Grissom, Ursula Hoffmann, Robert Mah, "Heteroatom Substituted Chromium Allyls: Synthetic Studies on Neocarzinostatin Chromophore Analogues," Tetrahedron Lett. 31, 6605 (1990).
73. Paul A. Wender and Charles K. Zercher, "Studies on DNA Cleaving Agents: Synthesis of a Functional Dynemicin Analogue," J. Am. Chem. Soc. 113, 2311 (1991).
72, Paul A. Wender and Mitch A. deLong, "Synthetic Studies on Arene-Olefin Cycloadditions. XII. Total Synthesis of (±)-Subergorgic Acid," Tetrahedron Lett. 31, 5429 (1990).
71, Paul A. Wender, Jeff McKinney, Chisato Mukai, "General Methodology for the Synthesis of Neocarzinostatin Chromophore Analogs: Intramolecular Chromium-Mediated Closures for Strained Ring Synthesis," J. Am. Chem. Soc. 112, 5369 (1990).
70. Paul A. Wender and Sunil Singh, "Synthetic Studies on Arene-Alkene Cycloadditions. 11. Total Synthesis of (-)-Retigeranic Acid." Tetrahedron Lett. 31, 2517 (1990).
69. Paul A. Wender, Robert Ternansky, Mitch deLong, Sunil Singh, Alan Olivero, Ken Rice," Arene-Alkene Cycloadditions and Organic Synthesis," Pure Appl. Chem. 62, 1597 (1990).
68. Paul A. Wender and Charles Manly, "Discovery of a New Fragmentation Reaction," J. Am. Chem. Soc., 112, 8579 (1990).
67. Paul A. Wender, Alan W. White, Frank E. McDonald, "Spiroannelation via Organobis(cuprates): 9,9-Dimethylspiro[4.5]decan-7-one, 9,9-dimethyl-)," Org. Synthesis, 70, 204 (1991).
66. Paul A. Wender and Frank E. McDonald, "Studies on Tumor Promoters. 10: Synthesis of the ABC Ring System of the Tiglianes and Daphnanes by a Zirconium-mediated Intramolecular Enyne Carbocyclization." Tetrahedron Lett. 31, 3691 (1990).
65. Paul A. Wender and Frank E. McDonald, "Studies on Tumor Promoters. 9: A Second Generation Synthesis of Phorbol," J. Am. Chem. Soc. 112, 4956 (1990).
64. Paul A. Wender, Lorenz Siggel, John M. Nuss, "Arene-alkene photocycloaddition reactions," Org. Photochem. 10, 357 (1989).
63. Paul A. Wender, Hiroshi Kogen, Hee Yoon Lee, John D. Munger, Jr., Robert S. Wilhelm, Peter D. Williams, "Studies on Tumor Promoters. 8: The Synthesis of Phorbol, "J. Am Chem. Soc. 111, 8957 (1989).
62. Paul A. Wender, Hee Yoon Lee, Robert S. Wilhelm, Peter Williams, "Studies on Tumor Promoters. VII: The Synthesis of a General Precursor of the Tiglianes, Daphnanes, and Ingenanes," J. Am. Chem. Soc. 111, 8954 (1989).
61. Paul A. Wender and Thomas E. Jenkins, "Nickel-Catalyzed Intramolecular [4+2] Dieneyne Cycloadditions: An Efficient New Method for the Synthesis of Polycycles Containing Cyclohexa-1,4-dienes," J. Am. Chem. Soc. 111, 6432 (1989).
60. Paul A. Wender, "Chemistry, Computers and Carcinogenesis," Pure Appl. Chem. 61, 469 (1989).
59. Paul A. Wender and Katherine Brighty, "Studies on Tumor Promoters VI: Complementary 1,4-Stereocontrol in Phorboid Cycloheptene Synthesis via the Divinylcyclopropane Rearrangement," Tetrahedron Lett. 29, 6741 (1988).
58. Paul A. Wender, Lorenz Siggel, John M. Nuss, "Arene-alkene Photocycloadditions," In Organic Photochemistry;, Albert Padwa, Ed.; Vol. 10; Marcel Dekker, Inc., New York, 1988; pp. 450-650.
57. Paul A. Wender, Cynthia M. Cribbs, Konrad F. Koehler, Nancy A. Sharkey, Cherry L. Herald, Yoshiake Komano, George R. Pettit, Peter M. Blumberg, "Modeling of the Bryostatins to the Phorbol Ester Pharmacophore on Protein Kinase C," Proc. Natl. Acad. Sci. USA 85, 7197 (1988).
56. Paul A. Wender, Nathan C. Ihle, Carlos R. D. Correia, "Nickel-Catalyzed Intramolecular [4+4] Cycloadditions: 4. Enantioselective Total Synthesis of (+)-Asteriscanolide," J. Am. Chem. Soc. 110, 5904 (1988).
55. Paul A. Wender, Tom von Geldern, Barry Levine, "Synthetic Studies on Arene-Olefin Cycloadditions. X: Total Synthesis of (±)-Laurenene," J. Am. Chem. Soc. 110, 4858 (1988).
54. Paul A. Wender, Michael Harmata, David Jeffrey, Chisato Mukai, Jean Suffert, "Studies on DNA-Active Agents: The Synthesis of the Parent Carbocyclic Subunit of Neocarzinostatin Chromophore A," Tetrahedron Lett. 29, 909 (1988).
53. Paul A. Wender, Alan W. White, "Organobiscuprates: A New Class of Reagents and Method for Spiroannelation," J. Am. Chem. Soc. 110, 2218 (1988).
52. Paul A. Wender, Christopher B. Cooper, "Indole Synthesis Based on Triazole Photochemistry: Total Synthesis of 7-Methoxymitosene," Tetrahedron Lett. 28, 6125 (1987).
51. Paul A. Wender, Nathan C. Ihle, "Nickel-Catalyzed Intramolecular [4+4] Cycloadditions: 2. Allylic Stereoinduction and Modelling Studies in the Preparation of Bicyclo[6.4.0]Dodecadienes," Tetrahedron Lett. 28, 2451 (1987).
50. Paul A. Wender, Marc L. Snapper, "Intramolecular Nickel Catalyzed Cycloadditions of Bis-Dienes: 3. Approaches to the Taxane System," Tetrahedron Lett. 28, 2221 (1987).
49. Paul A. Wender, Richard M. Keenan, Hee Yoon Lee, "Studies on Tumor Promoters: The First Synthesis of the Phorbol Skeleton," J. Am. Chem. Soc. 109, 4390 (1987).
48. Paul A. Wender, Carlos R.D. Correia, "Intramolecular Photo-Induced Diene-Diene Cycloadditions: A Selective Method for the Synthesis of Complex Eight-Membered Rings and Polyquinanes," J. Am. Chem. Soc. 109, 2523 (1987).
47. Paul A. Wender, John M. Schaus, Alan W. White, "General Methodology for cis-Hydroisoquinoline Synthesis. 3. A Sixteen Step Synthesis of Reserpine," Heterocycles 25, 263 (1987).
46. Paul A. Wender, Tom W. von Geldern, "Aromatic Compounds: Isomerisation and Cycloaddition" in Photochem. Org. Synth. J. Coyle, Ed.; The Royal Society of Chemistry, ISBN 0-85186-656-5, pp. 226-255 (1986).
45. Paul A. Wender, "Alkenes: Cycloaddition" in Photochemistry in Organic Synthesis, J. Coyle, Ed.; The Royal Society of Chemistry, ISBN 0-85186-656-5, pp. 163-188 (1986).
44. Paul A. Wender, Konrad F. Koehler, Robert S. Wilhelm, Peter D. Williams, Hee Yoon Lee, "Studies on tumor promoters: the first synthesis of the phorbol skeleton," In Stud. Org. Chem. 25 New Synth. Methodol Functl. Interesting Compd. pp.163-82. (Amsterdam)
43. Paul A. Wender, Konrad F. Koehler, Nancy A. Sharkey, Marie L. Dell'Aquila, Peter Blumberg, "Analysis of the Phorbol Ester Pharmacophore on Protein Kinase C as a Guide to the Rational Design of New Classes of Analogs," Proc. Natl. Acad. Sci. USA 83, 4214 (1986).
42. Paul A. Wender, Nathan C. Ihle, "Nickel-Catalyzed Intramolecular [4+4]-Cycloadditions: A New Method for the Synthesis of Polycycles Containing Eight-Membered Rings," J. Am. Chem. Soc. 108, 4678 (1986).
41. Paul A. Wender, Karl J. Fisher, "Seven-Membered Ring Synthesis Based on Arene-Olefin Cycloadditions: The Total Synthesis of (±)-Rudmollin," Tetrahedron Lett. 27, 1857 (1986).
40. Paul A. Wender, Christopher Cooper, "The Photochemistry of 1-Alkenylbenzotriazoles: Methodology for the Synthesis of Indoles," Tetrahedron Symposium in Print: General Synthetic Methods, 42, 2985 (1986).
39. Paul A. Wender, Konrad Koehler, Robert Wilhelm, Peter Williams, Richard Keenan, Hee Yoon Lee, "Tumor Promotion: Pharmacological and Synthetic Studies," in New Synthetic Methodology and Functionally Interesting Compounds, Z-I. Yoshida, Ed.; pp. 163-184, Elsevier Publishing Co., Amsterdam (1986).
38. Paul A. Wender, Dennis A. Holt, and Scott McN. Sieburth, "2-Alkenyl Carbinols from 2-Halo Ketones: 2-E-Propenylcyclohexanol," Organic Syntheses, A.S. Kende, Ed.; Vol 64 (10), Organic Syntheses Inc., USA (1985).
37. Paul A. Wender and Sunil K. Singh, "Synthetic Studies on Arene-olefin Cycloadditions-VIII. Total Syntheses of (±)-Silphiperfol-6-ene, (±))-7 aH-Silphiperfol-5-ene, and (±)-7bH-Silphiperfol-5-ene," Tetrahedron Lett. 26, 5987 (1985).
36. Paul A. Wender and Dennis A. Holt, "Macroexpansion Methodology III. Total Synthesis of (-)-(3Z)-Cembrene A," J. Am. Chem. Soc. 107, 7771 (1985).
35. Paul A. Wender and Donald J. Wolanin, "Total Synthesis of Quadrone and Terrecyclic Acid," J. Org. Chem 50, 4418 (1985).
34. Paul A. Wender, Robert J. Ternansky, and Scott McN. Sieburth, "An Enolate-Accelerated Cope Rearrangement," Tetrahedron Lett. 26, 4319 (1985).
33. Paul A. Wender and Robert J. Ternansky, "Synthetic Studies on Arene-Olefin Cycloadditions-VII: A Three-step Total Synthesis of (±)-Silphinene," Tetrahedron Lett. 26, 2625 (1985).
32. Paul A. Wender, "Selectivity in Excited State Chemistry." In Selectivity: A Goal for Synthetic Efficiency, W. Bartmann and B. Trost, Eds.; Verlag Chemie pp. 335-348 (1984).
31. Paul A. Wender and Alan W. White, "Methodology for the Facile and Regiocontrolled Synthesis of Indoles," In Tetrahedron Symposium in Print, Martin Kuehne, Ed. 3767 (1983).
30. Paul A. Wender and J. J. Howbert, "Synthetic Studies on Arene-Olefin Cycloadditions-VI: Two Syntheses of (±)-Coriolin," Tetrahedron Lett. 24, 5325 (1983).
29. Paul A. Wender and Geoffrey B. Dreyer, "Synthetic Studies on Arene-Olefin Cycloadditions-V. Total Synthesis of (±)-Isoiridomyrmecin," Tetrahedron Lett. 24, 4543 (1983).
28. Paul A. Wender, Dennis A. Holt, and Scott M. Sieburth, "Practical Method for a-Alkenyl Ketone Synthesis Based on a Facile Reductive Rearrangement of Alkynyl Halohydrins," J. Am. Chem. Soc. 105, 3348 (1983).
27. Paul A. Wender and Geoffrey B. Dreyer, Synthetic Studies on Arene-Olefin Cycloadditions. 4: Total Synthesis of (±)-Modhephene," J. Am. Chem. Soc. 104, 5805 (1982).
26. Paul A. Wender and J. J. Howbert, "Synthetic Studies on Arene Olefin Cycloadditions. III: Total synthesis of (±)-Hirsutene," Tetrahedron Lett. 23, 3983 (1982).
25. Paul A. Wender and Stephen L. Eck, "The Olefin Metathesis/Transannular Ene Sequence: A Method for the Stereocontrolled Synthesis of Trans-Decalin Derivatives. 3. Total Synthesis of (±)-Warburganal," Tetrahedron Lett. 23, 1871 (1982).
24. Paul A. Wender, Scott McN. Sieburth, Joseph J. Petraitis, and Sunil K. Singh, "Macroexpansion Methodology: Medium Ring Synthesis Based on an Eight Unit Ring Expansion Process," Tetrahedron Symposium in Print, E.J. Corey, Ed.; Vol. 37 (23) 3967 (1981).
23. Paul A. Wender and Geoffrey B. Dreyer, "Synthetic Studies on Arene-Olefin Photocycloadditions. II. Total Synthesis of (±)-Isocomene," In Tetrahedron Symposium in Print, Leo Paquette, Ed.; 37, 4445 (1981).
22. Paul A. Wender and Scott McN. Sieburth, "Macroexpansion Methodology: An Efficient Eight Unit Ring Expansion," Tetrahedron Lett. 22, 2471 (1981).
21. Paul A. Wender, Jeanette Erhardt, and Leo Letendre, "Reactions of Allylically Substituted Enolates with Organometallic Reagents: A Convenient Source of Enolonium Ion Equivalents," J. Am. Chem. Soc. 103, 2114 (1981).
20. Paul A. Wender and Alan W. White, "Methodology for Indole Synthesis," Tetrahedron Lett. 22, 1475 (1981).
19. Paul A. Wender and J. J. Howbert, "Synthetic Studies on Arene-Olefin Photocycloadditions: Total Synthesis of (±)-Cedrene," J. Am. Chem. Soc. 103, 688 (1981).
18. Paul A. Wender, John M. Schaus, and Alan W. White, "A General Methodology for cis-Hydroisoquinoline Synthesis: Synthesis of Reserpine," J. Am. Chem. Soc. 102, 6157 (1980).
17. Paul A. Wender and John C. Lechleiter, "Total Synthesis of (±)-Isabelin," J. Am. Chem. Soc. 102, 6340 (1980).
16. Paul A. Wender, Craig L. Hillemann, and Mike Szymonifka, "An Approach to the Tiglianes, Daphnanes, and Ingenanes via the Divinylcyclopropane Rearrangement," Tetrahedron Lett., 21, 2205 (1980).
15. Paul A. Wender and Leo J. Letendre, "The Olefin Metathesis-Transannular Ene Sequence: A Method for the Stereocontrolled Synthesis of Trans-Decalin Derivatives. II. Formal Eudesmane Syntheses." J. Org. Chem. 45, 367 (1980).
14.Paul A. Wender and John C. Hubbs, "The Olefin Metathesis-Transannular Ene Sequence: A Method for the Stereocontrolled Synthesis of Trans-Decalin Derivatives. I. Total Synthesis of (±)-Calameon," J. Org. Chem. 45, 365 (1980).
13. Paul A. Wender, John M. Schaus, and David C. Torney, "A General Method for cis-Hydroisoquinoline Synthesis," Tetrahedron Lett., 2485 (1979).
12. Paul A. Wender, Michael A. Eissenstat, and Michael P. Filosa, "A General Methodology for Pseudoquaiane Synthesis: Total Synthesis of (±)-Damsinic Acid and (±)-Confertin," J. Am. Chem. Soc. 101, 2196 (1979).
11. Paul A. Wender and John C. Lechleiter, "A Photochemically Mediated [4C+2C] Annelation. Synthesis of (±)-10-Epijunenol," J. Am. Chem. Soc. 100, 4321 (1978).
10. Paul A. Wender and John M. Schaus, "Imine Prototrophy: Synthetic Consequences in the Generation of Metalloenamines," J. Org. Chem. 43, 782 (1978).
9. Paul A. Wender and Michael A. Eissenstat, "The Regiospecific Generation of Lithioenamenes from a,b-Unsaturated Imines. An Alternative Method for the Reduction-Alkylation of Enones," J. Am. Chem. Soc. 100, 292 (1978).
8. P. A. Wender, M. A. Eissenstat, N. Sapuppo, and F. E. Ziegler, "Nitriles from Ketones: Cyclohexylnitrile," In Organic Syntheses.; W. A. Sheppard, Ed.; Vol. 58; J. Wiley and Sons; New York, 1978; p., 101
7. Frederick E. Ziegler and Paul A. Wender, "Methyldialkylcyanodiazenecarboxylates as Intermediates for Transforming Aliphatic Ketones into Nitriles," J. Org. Chem. 42, 2001 (1977).
6. Frederick E. Ziegler, Gary R. Reid, William L. Studt, and Paul A. Wender, "Stereochemistry of Dialkylcuprate Additions to Cyclopropylacryclic Esters. An Application to the Synthesis of (±)-Eremophilone," J. Org. Chem. 42, 1991 (1977).
5. Paul A. Wender and Stephen L. Eck, "Organobiscuprates. A Single-Step Spiro-annelation Method," Tetrahedron Lett. 14, 1245 (1977)
4. Paul A. Wender and John C. Lechleiter, "Methods for the Preparation of 1,5-Dienes: A Metathetical Route to Medium-Sized Carbocycles," J. Am. Chem. Soc. 99, 267 (1977).
3. Paul A. Wender and Michael P. Filosa, "A Facile Route to Divinylcyclopropanes. An Efficient Method for the Annelative Formation of Functionalized Cycloheptanes," J. Org. Chem. 41, 3490 (1976).
2. F. E. Ziegler and Paul A. Wender, "The Stereospecific Generation of the cis-Vicinal Methyls in Eremophilane and Valencane Sesquiterpenes: The Total Synthesis of (±)-Eremophilone and (±)-Epieremophilone," Tetrahedron Lett. 449 (1974).
1. F. E. Ziegler and Paul A. Wender, "The Base-Induced Decomposition of Methyl Dialkyl cyanodiazenecarboxylates. The Transformation of Ketones into Nitriles, a-Carbomethoxynitriles, and a-Methylnitriles," J. Am. Chem. Soc. 93, 4318 (1971).